Seema Shukla*, Sweta Gulati, Nitesh Goel, Shikha Modi, Amit Mittal and Subi Regmi

Department of Anaesthesia, Rajiv Gandhi Cancer Institute and Research Centre, India

*Corresponding Author: Seema Shukla, Department of Anaesthesia, Rajiv Gandhi Cancer Institute and Research Centre, India.

Received: May 18, 2026; Published: July 01, 2026

Background and Aims: Percutaneous radiofrequency ablation (PRFA) is a minimally invasive approach that employs needle targeted heat therapy for necrosis of hepatic tumour lesions. Despite of its advantages, patients often experience pain and anxiety during PRFA, necessitating the use of monitored anaesthesia care (MAC) with sedation to alleviate pain and ensure comfort during the procedure.

This study aims to evaluate the effectiveness of infiltration of Glisson’s Capsule with 2% Lignocaine in reducing intravenous anaesthetic requirements and ensuring patient’s comfort during MAC sedation for PRFA of hepatic tumours.

Methods: After approval from the ethical committee with the clinical trials registry, this prospective, randomized, controlled study was conducted. Fourteen patients fulfilling the inclusion criteria, randomly allocated into Group L (10 ml of 2% lignocaine infiltrated over Glisson’s capsule) or Group C (no infiltration) were included in this study. Intraoperative anaesthetic requirements (Ketamine boluses) along with intraoperative and postoperative VAS scores, sedation levels and haemodynamic parameters were recorded.

Results: The total dose of ketamine administered was lower in Group L (21.43 ± 6.90) as compared to Group C (58.57 ± 8.99) with statistical significance (P = 0.001) with duration of procedure comparable between the groups. Intraoperative and postoperative VAS scores and sedation levels were significantly lower in Group L with steady haemodynamic compared to Group C (P < 0.05).

Conclusion: Infiltration of Glisson's capsule was found to be a promising approach for reducing anaesthetic requirements, ensuring patient’s comfort with hemodynamic stability during PRFA of sub-capsular liver lesions.

Keywords: Monitored Anaesthesia Care Sedation; Radiofrequency Ablation; Liver Tumours

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Citation

Citation: Seema Shukla., et al. “Effect of Glisson’s Capsule Infiltration with 2% Lignocaine on Anaesthetic Drug Requirements During Monitored Anaes- thesia Care for Percutaneous Radiofrequency Ablation of Liver Tumors". Acta Scientific Medical Sciences 10.7 (2026): 31-38.

Copyright

Copyright: © 2026 Seema Shukla., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.