¹Department of Pharmaceutical Technology, School of Health and Medical Sciences, Adamas University, Barasat, Kolkata-700126, West Bengal, India
²Department of Pharmacology, GITAM School of Pharmacy, GITAM Deemed to be University, Visakhapatnam-530045, Andhra Pradesh, India
³Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, West Bengal, India

*Corresponding Author: Nandan Sarkar, Department of Pharmaceutical Technology, School of Health and Medical Sciences, Adamas University, Barasat, Kolkata-700126, West Bengal, India.

Received: October 13, 2025; Published: November 30, 2025

Abstract

Diabetes is a disease that occurs when your blood glucose, also called blood sugar, is too high. Glucose is your body’s main source of energy. The human body can make glucose, but glucose also comes from the food we consume. Insulin is a hormone made by the pancreas that helps glucose get into the cells to be used for energy. If anyone have diabetes, the body doesn’t make enough or any insulin or doesn’t use insulin properly. There are basically 2 types of diabetes, Type 1 diabetes is where blood glucose (sugar) level is too high because body can’t make a hormone called insulin. This happens because body attacks the cells in the pancreas that make the insulin, meaning is unable produce any at all. With type 2 diabetes the insulin in pancreas makes can’t work properly, or pancreas can’t make enough insulin. This means blood glucose (sugar) levels keep rising. Around 90% of people with diabetes in the UK have type 2. Antidiabetic drugs are medicines developed to stabilise and control blood glucose levels amongst people with diabetes. If diabetic patient will take Anti-Diabetic medication for Prolong time, the Anti-Diabetic drugs can show some adverse effect, like-Anorexia, Lactic acidosis, Mild Diarrhoea, Dyspepsia, Weight gain, Hypoglycaemia etc. But among these side effects we have observed that the major side effects are Arthralgia (joint Pain). In the present study we surveyed among 80 people and near about 50 people have diabetes at various age. Several People is used different types of medicine but among them majority used the drug is Metformin and Glimepiride. For the treatment of side effects about 87% people does not use any medication. The observed blood glucose level after taking antidiabetic medicine is around 110mg/dL. This comprehensive study will provide an idea about the various adverse effects, observed due to prolonged use of antidiabetic drugs. Though a more detailed volunteer study is further required to draw a final conclusion.

 Keywords: Diabetes; Anti Diabetic Drugs; Metformin; Glimepiride; Blood Glucose Level;; Insulin

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Citation

Citation: Nandan Sarkar., et al. “Comprehensive Assessment of Long-Term Safety Concerns in Antidiabetic Drug Therapy”.Acta Scientific Medical Sciences 9.12 (2025): 64-71.

Copyright

Copyright: © 2025 Nandan Sarkar., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.