Combination of Acupuncture and Exosome Intranasal as Alternative Therapy in Stroke Patient Rehabilitation

David Sungahandra and Cicilia Windiyaningsih*

University Respati Indonesia, Indonesia

*Corresponding Author: Cicilia Windiyaningsih, University Respati Indonesia, Indonesia.

Received: October 01, 2025; Published: October 28, 2025

Abstract

Stroke is a leading cause of long-term disability, requiring comprehensive rehabilitation approaches. The combination of acupuncture therapy and exosome application has emerged as an innovative alternative to enhance stroke patient recovery. Acupuncture stimulates specific points to modulate neural function and promote neuroplasticity, while exosomes, as extracellular vesicles containing growth factors and bioactive molecules, help repair damaged neural tissues. This combined approach is expected to provide synergistic effects in improving motor and cognitive functions after stroke and to accelerate rehabilitation. This article discusses the potential mechanisms of action, clinical benefits, and challenges in implementing acupuncture and exosome combination therapy as an alternative in stroke rehabilitation programs.

 Keywords: Stroke; Acupuncture; Exosomes; Rehabilitation; Neuroplasticity

References

1. Feigin VL., et al. “Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019”. Lancet Neurology10 (2021): 795-820.
2. Langhorne P., et al. “Stroke rehabilitation”. The Lancet9778 (2011): 1693-1702.
3. Lee SH and LS. “Clinical effectiveness of acupuncture on stroke recovery: A systematic review”. Complementary Therapies in Medicine 34 (2017): 104-112.
4. Kalluri R and LeBleu VS. “The biology, function, and biomedical applications of exosomes”. Science (1979) 367.6478 (2020).
5. Chen J., et al. “Exosome therapy for stroke recovery: recent advances and challenges”. Frontiers in Cell Neuroscience 15 (2021).
6. Wang C., et al. “Combining acupuncture and stem cell-derived exosomes for stroke rehabilitation”. Neural Regeneration Research4 (2022): 753-760.
7. Zhang S., et al. “Electro-Acupuncture Promotes the Differentiation of Endogenous Neural Stem Cells via Exosomal microRNA 146b After Ischemic Stroke”. Frontiers in Cell Neuroscience 14 (2020).
8. Yin W., et al. “Exosomes: the next-generation therapeutic platform for ischemic stroke”. Neural Regeneration Research 20 (2025).
9. Zhang S., et al. “Acupuncture promotes functional recovery after stroke by enhancing brain neuroplasticity”. Neural Regeneration Research5 (2018): 776-782.
10. Zhong LL., et al. “Would integrated Western and traditional Chinese medicine have more benefits for stroke rehabilitation? A systematic review and meta-analysis”. Stroke Vascular Neurology1 (2022): 77-85.

Citation

Citation: David Sungahandra and Cicilia Windiyaningsih. “Combination of Acupuncture and Exosome Intranasal as Alternative Therapy in Stroke Patient Rehabilitation”.Acta Scientific Medical Sciences 9.11 (2025): 35-39.

Copyright

Copyright: © 2025 David Sungahandra and Cicilia Windiyaningsih. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.