Pancreatic Ganglioneuroma: A Literature Review and Clinical Case

Stepanova YuA¹*, Gurmikov BN², Gruzdev IS³, Kalinin DV⁴, Zhavoronkova OI⁵, Shevchenko TV⁶ and Ruzavin VS⁶

¹Doctor of Medical Science, Professor, Leading Researcher, Ultrasound Diagnostics Department, A.V. Vishnevsky National Medical Research Center of Surgery, Moscow, Russia
²Doctor of Medical Science, Surgeon, Oncologist, Head of the Oncological Diseases Department of Surgical Methods for Treating, A.V. Vishnevsky National Medical Research Center of Surgery, Moscow, Russia
³Candidate of Medical Sciences, Research Associate at Roentgenology and Magnetic Resonance Department, A.V. Vishnevsky National Medical Research Center of Surgery, Moscow, Russia
⁴Candidate of Medical Sciences, Head of Pathological Anatomy Department, A.V. Vishnevsky National Medical Research Center of Surgery, Moscow, Russia
⁵Candidate of Medical Sciences, Senior Researcher, Ultrasound Diagnostics Department, A.V. Vishnevsky National Medical Research Center of Surgery, Moscow, Russia
⁶Candidate of Medical Sciences, Surgeon, Oncological Diseases Department of Surgical Methods for Treating, A.V. Vishnevsky National Medical Research Center of Surgery, Moscow, Russia

*Corresponding Author: Stepanova YuA, Doctor of Medical Science, Professor, Leading Researcher, Ultrasound Diagnostics Department, A.V. Vishnevsky National Medical Research Center of Surgery, Moscow, Russia.

Received: July 24, 2025; Published: October 06, 2025

Abstract

Pancreatic ganglioneuroma is an extremely rare pathology in routine medical practice without specifically formulated modern protocols and guidelines for diagnosis and treatment. Accurate diagnosis of pancreatic ganglioneuroma using instrumental methods at the preoperative stage is extremely difficult. Surgery resection with negative margins is the main treatment option and in most cases the only way to make a correct diagnosis.

We present our own clinical case of successful treatment of a 19-year-old woman with pancreatic head ganglioneuroma. A detailed path of diagnostic search, choice of surgical tactics, and the results of histological and immunohistochemical studies are presented.

Conclusion: In case of accidental detection of a pancreatic lesion that does not have distinctive radiology signs, ganglioneuroma should be considered in differential diagnostics even in older people, and biopsy is also justified.

 Keywords: Pancreatic Ganglioneuroma, Diagnostics, Radiology Characteristics, Surgery Treatment, Morphology, Immunohistochemistry

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Citation

Citation: Stepanova YuA., et al. “Pancreatic Ganglioneuroma: A Literature Review and Clinical Case”.Acta Scientific Medical Sciences 9.11 (2025): 05-11.

Copyright

Copyright: © 2025 Stepanova YuA., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.