Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Research Article Volume 9 Issue 7

Bronchoscopy-Guided Pathogen Identification in Suspected Lower Respiratory Tract Infections

Marco Umberto Scaramozzino1* and Tiziana Bruno2

1Head of Thoracic Endoscopy and Rehabilitation Pulmonology Services, Villa Aurora Hospital Reggio Calabria, Italy
2Thoracic Endoscopy Service, Villa Aurora Hospital Reggio Calabria, Italy

*Corresponding Author: Marco Umberto Scaramozzino, Head of Thoracic Endoscopy and Rehabilitation Pulmonology Services, Villa Aurora Hospital Reggio Calabria, Italy.

Received: June 12, 2025; Published: June 23, 2025

Abstract

Lower respiratory tract infections (LRTIs) continue to represent a diagnostic and therapeutic challenge due to their broad etiology and overlapping clinical features with non-infectious pulmonary diseases. This retrospective study evaluated the diagnostic contribution of bronchoscopy with bronchoaspirate analysis in 100 patients with suspected LRTIs between 2022 and 2025. Bronchoalveolar lavage (BAL) and targeted microbiological testing led to pathogen identification in 20% of cases, isolating both common and atypical organisms. Among the 20 positive cases, pathogens such as Legionella pneumophila, Mycobacterium intracellulare, and Pseudomonas aeruginosa were identified, highlighting the diagnostic superiority of bronchoscopic sampling compared to non-invasive techniques. The remaining 80% of cases had negative bronchoaspirate results, reinforcing bronchoscopy’s value even in excluding infections. Timely and accurate identification of causative pathogens facilitated appropriate antimicrobial therapy and improved clinical outcomes. Our findings underscore bronchoscopy’s essential role in the precise management of LRTIs.

 Keywords: Bronchoscopy, Bronchoaspirate; Lower Respiratory Tract Infections; BAL; Pathogen Identification; Diagnostic Yield

References

  1. Torres A., et al. “ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing”. European Respiratory Journal3 (2018): 1800630.
  2. Mandell LA., et al. “Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults”. Clinical Infectious Diseases2 (2007): S27-72.
  3. Niederman MS. “Aspiration Pneumonia”. The New England Journal of Medicine 8 (2001): 602-612.
  4. Pratter MR., et al. Chest4 (1983): 521-525.
  5. Herth FJF., et al. American Journal of Respiratory and Critical Care Medicine7 (2003): 963-968.
  6. Woodring JH. Radiology2 (1993): 389-394.
  7. Wiener RS., et al. Chest2 (2012): 388-397.
  8. Kvale PA. Chest5 (1998): 1311-1321.
  9. Murray PR., et al. Manual of Clinical Microbiology. ASM Press (2020).
  10. “M100 Performance Standards for Antimicrobial Susceptibility Testing” (2023).
  11. ATS/IDSA. American Journal of Respiratory and Critical Care Medicine7 (2019): e45-e67.
  12. Lee MK., et al. The International Journal of Tuberculosis and Lung Disease3 (2023): 295-300.
  13. Chastre J., et al. American Journal of Respiratory and Critical Care Medicine7 (2002): 867-903.
  14. Rello J., et al. Chest 2 (1997): 409-417.
  15. Phin N., et al. Lancet Infectious Disease10 (2014): 1011-1021.
  16. Diederen BMW. Clinical Microbiology Infection4 (2011): 395-413.
  17. Griffith DE., et al. “An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases”. American Journal of Respiratory and Critical Care Medicine4 (2007): 367-416.
  18. Murdoch DR. Clinical Infectious Diseases11 (2004): 1657-1664.
  19. Templeton KE., et al. Journal of Clinical Microbiology3 (2005): 1436-1440.
  20. Lee FE., et al. Current Opinion in Pulmonary Medicine3 (2010): 240-247.
  21. Dheda K., et al. “The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis”. Lancet Respiratory Medicine6 (2016): 456-466.
  22. Jain S., et al. “Community-Acquired Pneumonia Requiring Hospitalization among U.S. Adults”. The New England Journal of Medicine5 (2015): 415-427.
  23. Metlay JP., et al. JAMA 8 (2019): 716-725.
  24. IDSA/ATS Guidelines. Clinical Infectious Diseases6 (2019): e1-e77.
  25. Aliberti S., et al. Thorax 10 (2017): 928-936.
  26. Ewig S., et al. European Respiratory Journal5 (2001): 861-869.
  27. Gadsby NJ., et al. Thorax 10 (2016): 940-949.
  28. Marrie TJ. “Community-acquired pneumonia”. Clinical Infectious Diseases4 (1994): 501-513.
  29. Wunderink RG., et al. Chest6 (2006): 1579-1585.
  30. Huang DT., et al. JAMA 8 (2019): 717-725.

Citation

Citation: Marco Umberto Scaramozzino and Tiziana Bruno. “Bronchoscopy-Guided Pathogen Identification in Suspected Lower Respiratory Tract Infections”.Acta Scientific Medical Sciences 9.7 (2025): 85-87.

Copyright

Copyright: © 2025 Marco Umberto Scaramozzino and Tiziana Bruno. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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