Iffat Rahman¹, Tripti Rani Das², Sabiha Islam³, Bidisha Chakma³, Jinat Fatema³, Shah Noor Sharmin⁴, Farah Noor³ and Tanzina Iveen Chowdhury³*

¹Medical Officer, Department of Obstetrics and Gynecology, Aliahat Hospital, Bogra, Bangladesh
²Professor, Department of Obstetrics and Gynecology, Bangladesh Medical University (BMU), Dhaka, Bangladesh
³Associate Professor, Department of Obstetrics and Gynecology, BMU, Dhaka, Bangladesh
⁴Medical officer, Department of Obstetrics and Gynecology, BMU, Dhaka, Bangladesh

*Corresponding Author: Tanzina Iveen Chowdhury, Assistant Professor, Department of Obstetrics and Gynecology, Bangladesh Medical University, Dhaka, Bangladesh.

Received: May 23, 2025; Published: June 16, 2025

Abstract

Background: Preterm labor remains a principal cause of neonatal morbidity and mortality globally, with mostly high incidence in low- and middle-income countries like Bangladesh and across the Indian subcontinent. Despite worldwide efforts, early identification of preterm labor remains a challenge, highlighting the necessity for consistent, reachable biomarkers to recover maternal and neonatal outcomes in these areas.

Aim: To establish the comparison between maternal serum ferritin and C-reactive protein (CRP) levels in preterm labor.

Methods: A case-control study was conducted at the Department of Obstetrics and Gynecology, Bangladesh Medical University, from June 2022 to May 2023. A total of 130 pregnant women in labor (65 preterm, 65 full term) were registered using non-probability sampling technique. Serum ferritin and CRP levels were measured using Microparticle Enzyme Immunoassay (MEIA) and Particle Enhanced Turbidimetric Immunoassay (PETIA), methods, correspondingly. Data were analyzed with SPSS v26, p < 0.05 measured statistically significant. Ethical approval and informed consent were obtained.

Results: Maternal serum ferritin levels were significantly lower in preterm cases compared to full-term controls (mean ± SD: 1.98 ± 0.12 vs. 2.00 ± 0.00 ng/ml, p = 0.044). ROC curve analysis for ferritin at a cutoff ≤26 ng/ml presented a sensitivity of 60.1%, specificity of 84.6%, and overall accuracy of 90.0%. In contrast, CRP levels were significantly raised in the preterm group, with 81.5% display increased CRP compared to none in the full-term group (p < 0.001). ROC curve for CRP shown excellent power, confirming its higher predictive value for preterm labor.

Conclusion: CRP displayed significantly developed diagnostic correctness than serum ferritin in finding preterm labor. Its strong sensitivity and specificity support its potential as a valuable early marker in clinical assessment. Incorporating CRP testing may advance early detection and managing of preterm labor risk.

 Keywords: Preterm Labor; C-Reactive Protein; Serum Ferritin; Biomarkers; Maternal Health

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Citation

Citation: Tanzina Iveen Chowdhury., et al. “Comparison of Maternal Serum Ferritin and C-reactive protein Levels in the Diagnosis of Preterm Labor”.Acta Scientific Medical Sciences 9.7 (2025): 62-67.

Copyright

Copyright: © 2025 Tanzina Iveen Chowdhury., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.