Rasika R Giri*, Amol S Rakte and Mayuri N Pole

Department of Pharmaceutics, Indrayani Vidya Mandir’s, Krishnarao Bhegade Institute of Pharmaceutical Education and Research, Talegaon Dabhade, Pune-410507, Maharashtra, India

*Corresponding Author: Rasika R Giri, Department of Pharmaceutics, Indrayani Vidya Mandir’s, Krishnarao Bhegade Institute of Pharmaceutical Education and Research, Talegaon Dabhade, Pune-410507, Maharashtra, India.

Received: May 30, 2025; Published: June 09, 2025

Abstract

The low bioavailability, high intra- and inter-subject variability, and lack of dose proportionality problems of hydrophobic (water-repelling) medications can be improved with the help of the self-micro emulsifying drug delivery system (SMEDDS). For poorly soluble medications, self-emulsifying drug delivery systems (SEDDS) are a useful technique for improving solubility and bioavailability. The components of SEDDS and isotropic mixes are oils, surfactants, and occasionally cosolvents. Since thee formulations and methods can result in microemulsions or fine oil-in-water (o/w) emulsions following mild stirring and water phase dilution in the GI tract, they can be a good choice for lipophilic drugs with dissolution rate-limited absorption. This paper provides an overview of the many biopharmaceutical components, kinds, production processes, attributes, constraints, and potential applications of SEDDS. The development of the solid self-emulsifying dosage form and delivery mechanism for SEDDS is emphasized, as is the assessment of SEDDS and its applications.

 Keywords: Bioavailability; Drug Delivery System; Liposomes; Microemulsion; Oil-In-Water; Poor Water Solubility; Self-Micro Emulsifying

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Citation

Citation: Rasika R Giri., et al. “Advancement in Formulation Strategies for Microemulsion and Self Emulsifying System: A Comprehensive Review”.Acta Scientific Medical Sciences 9.6 (2025): 05-13.

Copyright

Copyright: © 2025 Rasika R Giri., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.