Rajiv Khadge¹, Mahesh Raj Sigdel², Roshan Pandit³, Bharat Jha¹ and Binod Kumar Yadav^1,3*

¹Department of Biochemistry, Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal
²Department of Nephrology, Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, Nepal
³Madhesh Institute of Health Sciences, Janakpurdham, Madhesh Province, Nepal

*Corresponding Author: Binod Kumar Yadav, Department of Biochemistry, Maharajgunj Medical Campus, Institute of Medicine,Tribhuvan University, Kathmandu, Nepal and Madhesh Institute of Health Sciences,Janakpurdham, Nepal.

Received: March 24, 2025; Published: May 22, 2025

Abstract

Introduction: Chronic kidney disease (CKD) poses significant health risks, including early death, reduced quality of life, and higher healthcare costs. It is linked to complications like cardiovascular disease, hyperlipidemia, anemia, and metabolic bone disease. This study aims to assess thyroid function in CKD patients.

Methods: A cross-sectional study was conducted among the CKD patients and apparently healthy participants at Tribhuvan University Teaching Hospital (TUTH), Kathmandu. Demographic features were noted, and patients' blood samples were analyzed for Thyroid Stimulating Hormone (TSH), Free Thyroxine (fT4), Free triiodothyronine(fT3) and creatinine.

Result: Among the total 110 CKD patients, thyroid dysfunction was observed in 29 (26.36%) patients. The prevalence of thyroid dysfunction significantly increased with CKD progression, rising from 13.33% in stage 3 to 40.54% in stage 4. However, a decline in prevalence was observed in stage 5, with thyroid dysfunction detected in only 10 (32.25%) patients. Subclinical hypothyroidism (17.27%) was the most prevalent form of thyroid dysfunction, followed by overt hypothyroidism (3.6%). A significant inverse correlation was found between the stage of CKD and mean free T3 levels (p-value < 0.05), indicating a progressive decline in free T3 with advancing CKD.

 Conclusions: This study found a strong link between CKD and thyroid dysfunction, especially hypothyroidism. The prevalence of thyroid dysfunction was higher in people with more severe CKD. This highlights the need for regular thyroid checkup in individuals with CKD.

 Keywords: Chronic Kidney Disease; Thyroid Dysfunction; Subclinical Hypothyroidism; TSH

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Citation

Citation: Binod Kumar Yadav., et al. “Thyroid Dysfunction in Chronic Kidney Disease Patients”.Acta Scientific Medical Sciences 9.6 (2025): 115-121.

Copyright

Copyright: © 2025 Binod Kumar Yadav., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.