Rawan Sahari¹*, Malak Saeed Alshahrani¹, Naif Alonazi¹, Shahad Naif Alotaibi², Razan Yahya Salem Yahya³, Abeer Ibrahim Alsulami³, Futun Nahi Almutairi¹, Teif Azar Alanzi¹, Samar Mohammed Bahkali¹ and Bashayer Yousef Alanazi¹

¹Respiratory Therapy Technician, Respiratory Care Services, Pediatric Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia
²Respiratory Therapy Specialist, Respiratory Care Services, Pediatric Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia
³Respiratory Therapy Specialist, Respiratory Care Services, Armed Forces Hospital, Dhahran, Saudi Arabia

*Corresponding Author: Respiratory Therapy Technician, Respiratory Care Services, Pediatric Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Received: April 21, 2025; Published: May 09, 2025

Abstract

Study Aim: The study aim to compare HFOV with alternative breathing techniques in terms of clinical outcomes, complications, and long-term impacts, and to evaluate the effectiveness of HFOV in enhancing oxygenation, ventilation duration, and neonatal survival rates.

Method: The PRISMA guideline was followed in the course of our investigation. We looked for publications published between 2012 and 2024 using the electronic databases PubMed, Cochrane, and Scopus. Our search targeted cohort studies and randomized controlled trials; studies that evaluate various neonatal breathing techniques; studies that use quantitative outcome measures; and studies involving newborns with respiratory distress syndromes. We exclude studies involving older infants, children, or adults, case reports, editorials, expert comments, narrative reviews, studies that do not employ HFOV as the major intervention, and studies that do not compare HFOV to another ventilation method.

Result and Discussion: In newborns with severe respiratory distress, HFOV is a successful but not selective breathing technique that offers benefits in lung preservation and oxygenation; nevertheless, its impact on survival and long-term results is still up for discussion. Early initiation, usage in certain patients, and combination with other supportive therapies (surfactant therapy) result in improved outcomes for HFOV. Long-term follow-up research and randomized controlled trials are advised to enhance HFOV procedures, reduce complications, and improve neonate outcomes in general.

 Keywords: High-Frequency Oscillatory Ventilation; Neonates; Premature Infants; Respiratory Distress Syndrome

References

1. Elgin TG., et al. “Ventilator Management in Extremely Preterm Infants”. Neoreviews10 (2022): e661-676.
2. Johnson AH., et al. “High-Frequency Oscillatory Ventilation for the Prevention of Chronic Lung Disease of Prematurity”. The New England Journal of Medicine 9 (2002): 633-642.
3. Ackermann BW., et al. “High-frequency ventilation in preterm infants and neonates”. Pediatric Research7 (2023): 1810-1818.
4. Berger TM., et al. “The Journey Towards Lung Protective Respiratory Support in Preterm Neonates”. Neonatology 4 (2013): 265-274.
5. Shetty S and Greenough A. “Neonatal ventilation strategies and long-term respiratory outcomes”. Early Human Development11 (2014): 735-739.
6. Page MJ., et al. “The PRISMA 2020 statement: an updated guideline for reporting systematic reviews”. BMJ (2021): n71.
7. Yang G., et al. “The clinical effects of high-frequency oscillatory ventilation in the treatment of neonatal severe meconium aspiration syndrome complicated with severe acute respiratory distress syndrome”. BMC Pediatrica1 (2021): 560.
8. Chen DM., et al. “Efficiency of high-frequency oscillatory ventilation combined with pulmonary surfactant in the treatment of neonatal meconium aspiration syndrome”. International Journal of Clinical and Experimental Medicine 8 (2015): 14490-14496.
9. Liu K., et al. “HFOV vs CMV for neonates with moderate-to-severe perinatal onset acute respiratory distress syndrome (NARDS): a propensity score analysis”. European Journal of Pediatrics7 (2021): 2155-2164.
10. Salvo V., et al. “First intention high-frequency oscillatory and conventional mechanical ventilation in premature infants without antenatal glucocorticoid prophylaxis”. Pediatric Critical Care Medicine 1 (2021): 72-79.
11. Singh SN., et al. “High frequency oscillatory ventilation versus synchronized intermittent mandatory ventilation in preterm neonates with hyaline membrane disease: A randomized controlled trial”. Indian Pediatrics5 (2012): 405-408.
12. Sun H., et al. “High-Frequency Oscillatory Ventilation Versus Synchronized Intermittent Mandatory Ventilation Plus Pressure Support in Preterm Infants With Severe Respiratory Distress Syndrome”. Respiratory Care2 (2014): 159-169.
13. Cools F., et al. “Elective high frequency oscillatory ventilation versus conventional ventilation for acute pulmonary dysfunction in preterm infants”. Cochrane Database System Review 3 (2015).
14. Truffert P., et al. “Neuromotor Outcome at 2 Years of Very Preterm Infants Who Were Treated With High-Frequency Oscillatory Ventilation or Conventional Ventilation for Neonatal Respiratory Distress Syndrome”. Pediatrics4 (2007): e860-865.
15. Wang C., et al. “Mechanical ventilation modes for respiratory distress syndrome in infants: a systematic review and network meta-analysis”. Critical Care1 (2015): 108.
16. Hsu JF., et al. “Therapeutic effects and outcomes of rescue high-frequency oscillatory ventilation for premature infants with severe refractory respiratory failure”. Scientific Report1 (2021): 8471.
17. Myers M., et al. “High-frequency oscillatory ventilation: A narrative review”. Canadian Journal of Respiratory Therapy 55 (2019): 40-46.

Citation

Citation: Rawan Sahari., et al. “Utilization and Outcome of High-Frequency Oscillatory Ventilation in Neonates and Premature Infants; Systematic Review”.Acta Scientific Medical Sciences 9.6 (2025): 30-36.

Copyright

Copyright: © 2025 Rawan Sahari., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.