Comparative Study of Interleukin-6, Interleukin-1B Levels and Iron Profile Among Sudanese Rheumatoid Arthritis Patients with Iron Deficiency Anemia
Rouaa Babikir Ahmed1*, Khalid Mohamed Khalid Elhussain1,2,
Babiker Ahmed Mohammed3, Doaa Abdullah Gasim4, Elyasaa Ahmed Gubartalla
Ali5, Manal Mohammed Khalid Elhussien6, Nora Nahal Bouderba7,
Mohammed Babiker Omer8, Rufaida Abdalla Ahmed9, Khalid Babikir
Ahmed10and Ahmed Babekir Abdalla11
1Omdurman Islamic University, Faculty of Medical Laboratory Sciences, Sudan
2Omdurman Ahlia University, Faulty of Medicine, Sudan
3Karary University, Faculty of Medical Laboratory Sciences, Sudan
4International University of Africa, Sudan
5Institute of Endemic Diseases (IEND), Khartoum University, Sudan
6Al-Mughtaribeen University, Faulty of Medicine, Sudan
7University Tahri Mohammed, Faculty of Sciences of Nature and Life, Biology Department, Bechar, Algeria
8Al-Neelain University, Faculty of Medical Laboratory Science, Sudan
9Royal Bournemouth Hospital, Bournemouth, Dorset, UK
10,11Modern Medical Center, Khartoum, Sudan
*Corresponding Author: Rouaa Babikir Ahmed, Omdurman Islamic University, Faculty of Medical Laboratory Sciences, Sudan.
February 21, 2023; Published: March 02, 2023
Aims: This study aimed to evaluate IL-6 and IL-1B levels and the iron profile (serum iron, ferritin, TIBC and TS%) in rheumatoid arthritis Sudanese patients.
Study Design: Case control. study.
Place and Duration of Study: This study was conducted at the Omdurman Islamic University, Sudan between 2018 and 2021.
Methodology: This study was conducted on 63 RA patients and 63 healthy individuals as control between 2018 and 2021. ELISA were used to measure the levels of IL-6and IL-1B, while the iron profile were carried out using automated chemical analyzer, the Transferrin saturation percentage TS% was calculated using the formula: TS (%)= [serum iron (ug/dl)/serum transferring (mg/dl)]17.
Result: IL-6 and IL1B levels were increased in anemic RA patients. In all patients, 98.4% of IL-6 levels and 28.5% of IL-1B levels had risen. IDA was common with 77% of anemic RA patients, their serum iron, ferritin and TS% show significant decrease. There was significant negative correlation between serum iron, ferritin, TIBC, and TS% with IL-6 in RA patients. There was statistically significant positive correlation between serum iron and IL1B in RA patients group.
Conclusion: The levels of IL-1β, IL-6 increased in RA patients and IDA showed 77% in case while there was association between IL-1β, IL-6 and serum iron in case. IDA is the most common and serious blood abnormality seen in RA. All of the above makes IL-1β, IL-6 and IDA with pivotal role in the pathophysiology of RA and this may affect the desirable option in the treatment of RA.
Keywords: Interleukin-6 (IL-6); Interleukin-1B (IL-1B); Rheumatoid Arthritis (RA); Enzyme-linked Immunosorbent Assay (ELISA); Transferrin Saturation Percentage (TS%); Total Iron Binding Capacity (TIBC); Iron Deficiency Anemia (IDA)
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