Mamun Al Mahtab¹*,Abdur Rahim², Musarrat Mahtab³, Proshikha Saha⁴ and Sheikh Mohammad Fazle Akbar⁵

^1,2Interventional Hepatology Division, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
³Department of Biochemistry and Biotechnology, North South University, Dhaka, Bangladesh
⁴Deapartment of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
⁵Department of Gastroenterology and Metabology, Ehime University, Japan

*Corresponding Author: Mamun Al Mahtab, Head, Interventional Hepatology Division, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.

Received: May 16, 2022; Published: May 19, 2022

Abstract

Introduction: In a global, phase 3, multi-center,open label clinical trial combination of atezolizumab and bevacizumab has yielded encouraging results, including better survival benefit and safety in patients with unresectable hepatocellular carcinoma.

Methods: We conducted a real-life observational study in small number of Bangladeshi patents with unresectable HCC on the background of decompensated liver cirrhosis.

Results: We had 6 patients in our study and the patients took the drugs in diverse number of cycles. One of the patients who took six cycles of the drugs have been surviving for about 15 months. Atezolizumab and bevacizumab combination proved to be safe during 48 hours of follow up, however, long-term follow up had not been possible for all patients due to their unavailability after administration.

Conclusion: Atezolizumab and bevacizumab combination seem to have encouraging outcome with approved dosage and administration, however, clinical study with larger cohort should be accomplished in Bangladesh to properly assess its possible usage in Bangladeshi patients.

Keywords: Hepatocellular Carcinoma; Combination Immunotherapy; Atezolizumab; Bevacizumab

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Citation

Citation: Mamun Al Mahtab., et al. “Real Life Experience of Combining Atezolizumab (Immunotherapy) and Bevacizumab (Antiangiogenic Agent) in Patients with Unresectable Hepatocellular Carcinoma in Bangladesh”.Acta Scientific Medical Sciences 6.6 (2022): 227-230.

Copyright

Copyright: © 2022 Mamun Al Mahtab., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.