New-onset Anosmia Among COVID-19 Suspected Patients in a Tertiary Care Hospital, Cairo, Egypt
Nora Tarek Elsaid*, Hossam Attia Mohammed, Hazem Naguib Awad, Mohammed Elsayed1 and Ahmed Elshehawy2
1ENT clinical fellow at Ahmed Maher Teaching Hospital, Cairo, Egypt
2Otorhinolaryngology specialist at Ahmed Maher Teaching Hospital, Cairo, Egypt
*Corresponding Author: Nora Tarek Elsaid, ENT clinical fellow at Ahmed Maher Teaching Hospital, Cairo, Egypt.
Received:
February 17, 2022; Published: March 09, 2022
Abstract
Introduction: The pandemic caused by the SARS-CoV2 virus, which was first reported in Wuhan, China in late 2019 and quickly spread to 213 countries and territories. As we race to get a better understanding of its pathology and how to manage it, a few trends have been noticed. Among these is the anecdotal finding of patients reporting sudden loss of smell and taste as one of the preliminary, and sometimes only, symptom
Aim: This study aims to describe the characteristics of patients that present with new onset anosmia during the COVID-19 pandemic.
Methods: Sample will target patients that present to the Emergency COVID-19 clinic at Ahmed Maher Teaching Hospital. The study data will be collected by data collection forms filled out by the researchers. All patients presenting to the covid-19 Emergency clinic with new onset anosmia within a two-month period.
Results: Out of total 81 participants from whom data was collected, 15 cases had diminished sense of smell as preliminary symptom, and 6 cases had only that at time of swab., 38.5% of all positive patients had their olfactory function affected as preliminary symptom. Thus, we can say that almost one in three positive patients displays a diminished sense of smell as a preliminary symptom.
The mean duration of anosmia was 9.4 ± 10.4 days in cases with anosmia who were confirmed by PCR to be positive, as compared to 10.74 ± 9.39 in cases with anosmia who showed negative results; without significant difference (P = 0.660). Duration was < 7 days for 55% (11/20), 7-14 days for 20% (4/20), and > 14 days for 25% (5/20).
Conclusion: While anosmia has been proven to be an anecdotal finding in COVID-19 positive patients, the presence of new onset anosmia in patients during the COVID-19 era cannot be fully explained by the SARS- CoV-2 virus. However, as healthcare workers, wearing full PPE while dealing with anosmia patients is recommended, as anosmia could be a preliminary symptom and this could prevent infection.
Keywords: Anosmia; COVID-19; SARS-CoV2
References
- “Countries-where-coronavirus-has-spread” (2020).
- Korea S and Korea S. “Loss of sense of smell as marker of COVID-19 infection” 19-20.
- Park R and Cancer C. “SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients”. The New England Journal of Medicine 1 (2020): 12-14.
- “COVID-19 Statistics in Egypt” (2020).
- “WHO COVID-19 Dashboard” (2020).
- “The COVID-19 pandemic and the ENT specialist area : what is currently important?” Key words SARS-CoV-2 COVID-19. 2.
- Judson SD and Munster VJ. “Nosocomial transmission of emerging viruses via aerosol-generating medical procedures”. Viruses 10 (2019): 940.
- Ziegler CGK., et al. “SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues”. Cell (2020): 1016-1035.
- Brann DH., et al. “Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID- 19-associated anosmia”. Science Advances31 (2020): 1-28.
- Sungnak W., et al. “SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes”. Nature Medicine 26 (2020): 681-687.
- Hou YJ., et al. “Article SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract ll ll Article SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract”. (2020): 429-446.
- Hopkins C., et al. “Early recovery following new onset anosmia during the COVID-19 pandemic - an observational cohort study”. Journal of Otolaryngology - Head and Neck Surgery 49 (2020).
- Hummel T., et al. “Olfactory function in acute rhinitis”. Annals of the New York Academy of Sciences 616 (1998): 24.
- Eliezer M., et al. “Sudden and Complete Olfactory Loss Function as a Possible Symptom of COVID-19”. JAMA Otolaryngology–Head and Neck Surgery7 (2020): 674-675.
- Hu T., et al. “A comparison of COVID-19, SARS and MERS”. Peer Journal 8 (2020): 1-30.
- El-anwar MW., et al. “ENT manifestation in COVID-19 patients”. Auris Nasus Larynx (2020): 6-11.
- Kaye R., et al. “COVID-19 Anosmia Reporting Tool: Initial Findings”. Otolaryngology–Head and Neck Surgery (2020): 1-3.
- Wang X., et al. “Effect of gender on odor identification at different life stages: a meta-analysis”. Rhinology 5 (2019): 322-330.
- Yan CH., et al. “Self-reported olfactory loss associates with outpatient clinical course in Covid-19”. International Forum of Allergy and Rhinology 7 (2020): 821-831.
- Vaira LA., et al. “Objective evaluation of anosmia and ageusia in COVID-19 patients: Single-center experience on 72 cases”. Head and Neck6 (2020): 1252-1258.
- Agyeman AA., et al. “Smell and Taste Dysfunction in Patients With COVID-19: A Systematic Review and Meta-analysis”. Mayo Clinic Proceedings (2020).
- htt (2019).
- Fuchen W., et al. “A real-time site correction method and its application in earthquake early warning” 1 2 (2020): 1-7.
- Louie JK., et al. “Factors Associated With Death or Hospitalization Due to Pandemic 2009 Influenza A (H1N1) Infection in California” 302.17 (2007).
- “CDC Risk Factors for Flu Complications”.
- Noah TL., et al. Obese 9 (2017): 1324-1330.
- Viewpoint T and Rate OF. “Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy”. 2019 (2020): 2019-2020.
- Jennifer M. “Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention”. 323.13 (2020).
- “Relationship between the ABO Blood Group and the COVID-19”. Susceptibility (2020): 1-18.
- Temmel AFP., et al. “Characteristics of olfactory disorders in relation to major causes of olfactory loss”. Archives of Otolaryngology - Head and Neck Surgery 6 (2002): 635-641.
- Amer MA., et al. “Early recovery patterns of olfactory disorders in COVID-19 patients; a clinical cohort study”. American Journal of Otolaryngology and Head and Neck Surgery 6 (2020): 102725.
- Boscolo-Rizzo P., et al. “Evolution of Altered Sense of Smell or Taste in Patients With Mildly Symptomatic COVID-19”. JAMA Otolaryngology–Head and Neck Surgery 8 (2020): 729-732.
Citation
Copyright