Abstract

Madelung’s disease is a rare condition characterized by multiple and symmetrical deposits of adipose tissue concerning especially neck, shoulders, upper limbs and upper thorax. This lipomatous tissue could cause extrinsic compression or recurrent laryngeal nerve compression because of infiltration of fat [1,2].
In this case, we will describe a 66-year-old man affected by Madelung’s disease, with larynx-tracheal anatomical alteration, showed by CT scan and flexible laryngoscopy.

Keywords: Madelung’s Disease; Lipomatosis; Upper Airways; Larynx; Videorhinolaryngoscopy

References

1. Borges A., et al. “Laryngeal involvement in multiple symmetric lipomatosis: the role of computed tomography in diagnosis”. American Journal of Otolaryngology 18 (1997): 127-130.
2. Zhang XY., et al. “Madelung disease: manifestations of CT and MR imaging”. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 105 (2008): e57-e64.
3. Keller SM., et al. “Benign symmetrical lipomatosis”. Southern Medical Journal 11 (1986): 1428-1429.
4. Gemperli R., et al. “Tratamento cirúrgico da lipomatose simétrica múltipla: doença de Madelung”. Revista Paulista De Medicina 6 (1988): 313-316.
5. , et al. “Multiple symmetric lipomatosis may be the consequence of defective noradrenergic modulation of proliferation and differentiation of brown fat cells”. Journal of Pathology 198 (2002): 378-387.
6. Brea-García B., et al. “Madelung’s disease: comorbidities, fatty mass distribution, and response to treatment of 22 patients”. Aesthetic Plastic Surgery 37 (2013): 409-416.
7. Hirose A., et al. “Benign symmetric lipomatosis associated with alcoholism”. In- tern Medicine 45 (2006): 1001-1005.
8. Mevio E., et al. “Multiple symmetric lipomatosis: a review of 3 cases”. Case Report on Otolaryngology (2012): 910526.
9. Amicucci G., et al. “Madelung’s disease. Clinical case and review of the literature [Article in Italian]”. Minerva Chirurgica 53 (1998): 655-657.
10. Ahuja AT., et al. “Madelung disease: distribution of cervical fat and preoperative findings at sonography, MR, and CT”. AJNR American Journal of Neuroradiology 19 (1998): 707-710.
11. Plotnicov NA., et al. “Madelung’s disease (benign symmetric lipomatosis)”. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology3 (2018): e2018030.
12. Pinto CI., et al. “Madelung’s disease: revision of 59 surgical cases”. Aesthetic Plastic Surgery 41 (2017): 359-368.
13. R Herrnans., et al. Benign symmetric lipomatosis of the neck or Madelung- Launois-Bensaude syndrome, also known as Madelung's neck: CT findings in two cases (1994).
14. V Pinto., et al. “A case of severe obstructive sleep apnoea in Madelung’s disease treated by lateral pharyngoplasty”. The Journal of Laryngology and Otology (2017).
15. Oliven A., et al. “Mechanical parameters determining pharyngeal collapsibility in patients with sleep apnea”. Journal of Applied Physiology 109 (2010): 1037-1044.

Citation

Citation: Gabriella Cadoni., et al. “Madelung’s Disease and Upper Airway Involvement: A Case Report".Acta Scientific Medical Sciences 4.9 (2020): 08-11.

Copyright

Copyright: © 2020 Cașcaval Virginia., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.