Acta Scientific Medical Sciences (ISSN: 2582-0931)

Research Article Volume 4 Issue 3

Preliminary Study of Prostatic Fluid Levels of Zinc Concentration as the Biodosimeter of Males Exposure to Ionizing Radiation

Vladimir Zaichick1* and Sofia Zaichick2

1Radionuclide Diagnostics Department, Medical Radiological Research Centre, Obninsk, Russia
2Laboratory of Dr. Gabriela Caraveo Piso, Feinberg School of Medicine, Northwestern University, Chicago, USA

*Corresponding Author: Vladimir Zaichick, Radionuclide Diagnostics Department, Medical Radiological Research Centre, Obninsk, Russia.

Received: January 17, 2020; Published: February 08, 2020

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Abstract

  Among different bio dosimeters, there is a need in methods that can rapidly and accurately determine individual exposure to ionizing radiation during examination a big cohort of people, particularly men. In present study contents of trace elements in the prostatic fluid were investigated to search for a new biological dosimeter. Prostatic fluid samples were obtained from 15 men aged 38 - 77 years suffering from bladder cancer. All patients were treated with external (distant) gamma-ray therapy. Fractionated tumour irradiation was used with a total dose of 65 Gy. The tumour was daily irradiated with the dose ranged from 6 to 12 Gy. The prostate radiation dose was calculated according to the distribution of isodose levels within patient’s body during the simulation of external local gamma-ray irradiation of bladder tumour. Transrectal digital massage was used to obtain expressed prostatic fluid samples before and 2 - 4 times during radiation therapy for the energy dispersive X-ray fluorescent analysis. A day after the first irradiation of the prostate with the average dose 4.6 Gy to prostate concentration of zinc in the prostatic fluid was about three times lower the metal level before gamma-ray therapy. The dose detection threshold was calculated up to 0.1 Gy. The exponential function was the best for approximation the “dose-effect” dependence of the zinc level in prostatic fluid from the radiation exposure during external gamma-ray therapy of patients with bladder cancer.

Keywords: Prostate; Prostatic Fluid; Biomarkers; Trace Elements; Zinc; Biological Dosimetry

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Citation

Citation: Vladimir Zaichick and Sofia Zaichick. “Preliminary Study of Prostatic Fluid Levels of Zinc Concentration as the Biodosimeter of Males Exposure to Ionizing Radiation". Acta Scientific Medical Sciences 4.3 (2020): 27-33.




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