Abstract

  The prostate gland is subject to various disorders. The etiology and pathogenesis of these diseases are not well understood. Moreover, despite technological advancements, the differential diagnostics of prostate disorders has become progressively more complex and controversial. It was suggested that the measurement of Zn levels in expressed prostatic fluid (EPF) may be useful as a biomarker. This suggestion promoted more detailed studies of the Zn concentrations in the EPF of healthy subjects. The present study evaluated by systematic analysis the published data for Zn concentration analyzed in EPF of normal gland. It included 25 studies, all of which were published in the years from 1961 to 2018 and selected by searching the databases Scopus, PubMed, MEDLINE, ELSEVIER-EMBASE, Cochrane Library, and the Web of Science. The articles were analyzed and “Median of Means” and “Range of Means” were used to examine heterogeneity of Zn concentrations in EPF of apparently healthy men. The objective analysis was performed on data from the 25 studies, with more than 900 subjects. It was found that the range of means of Zn concentration reported in the literature for normal EPF varies widely from 47.1 mg/L to 825 mg/L with median of means 501 mg/L. Finally, because of small sample size and high data heterogeneity, we recommend other primary studies.

Keywords: Prostate; Prostatic Fluid; Biomarkers; Trace Elements; Zinc

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Citation

Citation: Vladimir Zaichick and Sofia Zaichick. “A Systematic Review of the Zinc Concentrations in the Prostate Fluid of Normal Gland". Acta Scientific Medical Sciences 4.1 (2020): 82-89.

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Copyright: © 2020 Vladimir Zaichick and Sofia Zaichick. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.