Roshan Kumar Mehta¹, K Supriya², Janardan Chaudhary²*, VP Rasal³ and Raj Kumar Mehta⁴

¹Department of Pharmacology, Universal College of Medical Sciences, Bhairahwa, Nepal
²Department of Anatomy, Faculty of Medicine, International Medical and Technological University, Dar Es Salaam, Tanzania
³Department of Pharmacology, KLE’S University, College of Pharmacy, Belgaum, Karnataka, India
⁴Nursing Management and Research, Chitwan Medical College, Chitwan, Nepal

*Corresponding Author: Janardan Chaudhary, Professor and Head, Department of Anatomy, Faculty of Medicine, International Medical and Technological University, Dar Es Salaam, Tanzania.

Received: March 16, 2018; Published: April 04, 2018

Citation: Janardan Chaudhary., et al. “Effect of Cucumis sativus Linn. in Liver Pathogenicity of Alloxan Induced Diabetic Rat”. Acta Scientific Medical Sciences 2.2 (2018).

Abstract

background: Diabetes mellitus (DM) is the most prevalent chronic disease which can be related with liver pathogenicity and its effect with induction of Cucumis sativus (CS) Linn. since its constituents play role in bioactive in glycogen, fat and as antioxidant lowering agent. Aim of the study is to observe effect of CS Linn. in liver of alloxan induced diabetic rat.

Materials and Methods:: Total twenty four albino wistar rats were randomly assigned in to four groups, each group consist of six rats Group I (control), Group II (diabetic control treated 120 mg/kg body weight single dose intraperitoneally), group III (diabetic treated with low dose of 200 mg/kg body weight/day) and Group IV (diabetic treated with high dose of 400 mg/kg body weight/day) for 21 days.

Results: Diabetic rat were found with reduced significantly in body weight (111.20 ± 9.48 gm), blood glucose level (364.0 ± 11. mg/dl), aspartate transaminase (AST) (112.8 ± 2.56 IU/L), Albumin (2.00 ± 0.13 mg%), and Alanine transaminase (ALT) (110.5 ± 2.67 IU/L). Liver pathogenicity of diabetic rat was revealed by lymphatic infiltration, intracellular vacuolation and apoptotic hepatocyte whereas low and high doses of CS treated diabetic rat reported significantly improved positive parameters in contrast to diabetic rat.

Conclusions: Oral Administration of CS Linn. shows an ameliorating effect to liver function and its pathogenicity of alloxan induced albino wistar rat.diabetic rat.

Keywords: Body Mass Index; Blood Glucose Level; Liver Function; Hepatopathogenicity

Copyright: © 2018 Janardan Chaudhary., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.