Shubodh N ¹ *, Radhika MD¹ and S Sumithra²

¹ Department of Emergency Medicine, Coimbatore Medical College, Tamil Nadu, India
² Department of Obstetrics and Gynecology, Coimbatore Medical College, Tamil Nadu, India

*Corresponding Author: Shubodh N, Department of Emergency Medicine, Coimbatore Medical College, Tamil Nadu, India.

Received: February 23, 2026 Published: February 28, 2026

Abstract

Background: Tumor lysis syndrome (TLS) is a fatal oncological emergency characterized by rapid release of intracellular contents following extensive breakdown of tumor cells. It is most commonly following with chemotherapy in hematological malignancies. Spontaneous tumor lysis syndrome (STLS), occurring in pregnancy is very rare, that to in absence of chemotherapy.

Methods: Retrospective institutional review of spontaneous tumor lysis syndrome in pregnancy.

Keywords: Spontaneous Tumor Lysis Syndrome; Pregnancy; Third Trimester; Acute Kidney Injury; Hematological Malignancy; Emergency Medicine

References

1. El-Sonbaty MR., et al. “Acute spontaneous tumor lysis syndrome in a pregnant woman with non-Hodgkin's lymphoma”. International Journal of Hematology 3 (2001): 386-389.
2. Cairo MS and Bishop M. “Tumour lysis syndrome: new therapeutic strategies and classification”. British Journal of Haematology 1 (2004): 3-11.
3. Gemici C. “Tumour lysis syndrome in solid tumors”. Clinical Oncology (Royal College of Radiologists) 10 (2006): 773-780.
4. Montesinos P., et al. “Tumor lysis syndrome in patients with acute leukemia”. Haematologica1 (2008): 67-74.
5. Mirrakhimov AE., et al. “Tumor lysis syndrome in solid tumors: An up-to-date review of the literature”. Rare Tumors 2 (2014): 5389.
6. Cardonick E., et al. “Leukemia in pregnancy: A case series and review of the literature”. Journal of Oncology (2010): 1-6.
7. Fernández Fernández C., et al. “Leucemia aguda mieloblástica engestante de 28 semanas. [Acute myeloblastic leukemia in a 28-week pregnant woman]”. Clinica e Investigacion en Ginecologia y Obstetricia 5 (2008): 184-186.
8. Shapira T., et al. “How I treat acute and chronic leukemia in pregnancy”. Blood Reviews 5 (2008): 247-259.
9. Middeke JM., et al. “Use of rasburicase in a pregnant woman with acute lymphoblastic leukaemia and imminent tumour lysis syndrome”. Annals of Hematology 3 (2014): 531-532.
10. Milojkovic D and Apperley JF. “How I treat leukemia during pregnancy”. Blood 7 (2014): 974-984.
11. Howard SC., et al. “The tumor lysis syndrome”. New England Journal of Medicine 19 (2011): 1844-1854.
12. Matsouka C., et al. “Acute lymphoblastic leukemia during gestation”. Medical Oncology2 (2008): 190-193.
13. Briggs GG., et al. “Drugs in pregnancy and lactation: A reference guide to fetal and neonatal risk”. Lippincott Williams & Wilkins (2011).
14. Webert KE., et al. “A retrospective 11-year analysis of obstetric patients with idiopathic thrombocytopenic purpura”. Blood 13 (2003): 4306-4311.
15. Provan D., et al. “International consensus report on the investigation and management of primary immune thrombocytopenia”. Blood 2 (2010): 168-186.
16. Santiago-López CJ., et al. “Leukemia during pregnancy”. Obstetrics and Gynecology International Journal 6 (2017): 150-154.
17. Milojkovic D and Apperley JF. “How I treat leukemia during pregnancy”. Blood7 (2014): 974-984.
18. Brenner B., et al. “Haematological cancers in pregnancy”. The Lancet9815 (2012): 580-587.

Citation

Citation: Shubodh N., et al. “Spontaneous Tumor Lysis Syndrome in the Third Trimester of Pregnancy: A Rare and Life-Threatening Case Report". Acta Scientific Cancer Biology 10.2 (2026): 03-05.

Copyright

Copyright: © 2026 Shubodh N., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.