Hsiang-Yin Hsueh*

Department of Cell and Molecular Biology, The Ohio State University, United States of America

*Corresponding Author: Hsiang-Yin Hsueh, Department of Cell and Molecular Biology, The Ohio State University, United States of America.

Received: October 28, 2025; Published: February 01, 2026

Abstract

Cancer biology has entered an era where disease monitoring is no longer restrained to invasive tissue biopsies. The detection of tumor-derived materials in blood and other body fluids is reshaping how we understand, detect, and treat cancer. Among its components, circulating tumor DNA (ctDNA) stands out as a minimally invasive window into the evolving genetic and epigenetic landscape of tumors. This editorial reflects on recent advances, ongoing challenges, and future directions in leveraging ctDNA to reshape our biological and clinical understanding of cancer.

Keywords: Liquid Biopsy; Circulating Tumor DNA; Cancer Biology; Tumor Heterogeneity; Early Detection; Precision Oncology

References

1. Ma L., et al. “Liquid biopsy in cancer current: status, challenges and future prospects”. Signal Transduction and Targeted Therapy 1 (2024): 336.
2. Lone SN., et al. “Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments”. Molecular Cancer1 (2022): 79.
3. Ji J., et al. “Circulating Tumor DNA Testing in Curatively Resected Colorectal Cancer and Salvage Resection”. JAMA Network Open12 (2024): e2452661.
4. Bayle A., et al. “Liquid versus tissue biopsy for detecting actionable alterations according to the ESMO Scale for Clinical Actionability of molecular Targets in patients with advanced cancer: a study from the French National Center for Precision Medicine (PRISM)”. Annals of Oncology12 (2022): 1328-1331.
5. Sivapalan L., et al. “Liquid biopsy approaches to capture tumor evolution and clinical outcomes during cancer immunotherapy”. Journal of Immunotherapy Cancer1 (2023): e005924.
6. Stejskal P., et al. “Circulating tumor nucleic acids: biology, release mechanisms, and clinical relevance”. Molecular Cancer1 (2023): 15.
7. Desai A and Lovly CM. “Challenges in the implementation of ultrasensitive liquid biopsy approaches in precision oncology”. Journal of Immunotherapy Cancer6 (2023): e006793.

Citation

Citation: Hsiang-Yin Hsueh. “Advances in Liquid Biopsy and Circulating Tumor DNA: A New Era in Cancer Detection and Monitoring". Acta Scientific Cancer Biology 10.2 (2026): 01-02.

Copyright

Copyright: © 2026 Hsiang-Yin Hsueh. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.