Testicular mesothelioma emerges as a malignant mesenchymal neoplasm engendered from serosa of tunica vaginalis. Tumefaction is associated with an aggressive biological course, akin to neoplasms confined to the peritoneal cavity. Of mesenchymal genesis, testicular mesothelioma is extremely exceptional and configures < 1% of mesotheliomas. Characteristically, tumefaction arises within middle aged to elderly population. A male preponderance is encountered [1,2]. Mean age of disease emergence is 53 years whereas neoplasm may occur within 12 years to 76 years. Testicular mesothelioma commonly emerges in individuals > 50 years whereas < 10% instances occur < 25 years. Paediatric population may expound the lesion.

References

1. Barbera V and Rubino M. “Papillary mesothelioma of the tunica vaginalis”. Cancer 10 (1957): 183-189.
2. Gilbert A., et al. “Metastatic Mesothelioma of the Tunica Vaginalis Presenting as Scrotal and Abdominal Nodules: A Case Report and Review of the Literature”. The American Journal of Dermatopathology 1 (2025): e6-e11.
3. Sweeney T., et al. “Identification and Management of Testicular Mesothelioma Identified Intraoperatively: A Case Series”. Cureus 5 (2024): e61190.
4. Gaddam SJ and Chesnut GT. “Testicle Cancer”. Stat Pearls International. Treasure Island, Florida (2023).
5. Shaker N., et al. “Malignant Para-Testicular Mesothelioma: A Rare Presentation in the Tunica Vaginalis of an Elderly Male With No Prior Asbestos Exposure”. International Journal of Surgical Pathology 32 (2024): 1117-1122.
6. Stella S., et al. “Mesothelioma of the Tunica Vaginalis Testis: Diagnostic and Therapeutic Management. A Comprehensive Review, 1982-2024”. Cancers 16 (2024): 3956.
7. Chys B., et al. “Well differentiated papillary mesothelioma of the tunica vaginalis: Case report”. Acta Chirurgica Belgica 123 (2023): 555-558.
8. Jiang Y., et al. “A rare malignant mesothelioma of the tunica vaginalis testis: A case report”. Oncology Letters 27 (2024): 172.
9. Grogg JB., et al. “Clinicopathological characteristics and outcomes in men with mesothelioma of the tunica vaginalis testis: Analysis of published case-series data”. Journal of Cancer Research and Clinical Oncology 147 (2021): 2671-2679.
10. Marinaccio A., et al. “Association between asbestos exposure and pericardial and tunica vaginalis testis malignant mesothelioma: A case-control study and epidemiological remarks”. Scandinavian Journal of Work, Environment and Health 46 (2020): 609-617.
11. Image 1 Courtesy: Sage Journals
12. Image 2 Courtesy: Nature.com

Citation

Citation: Anubha Bajaj., et al. “Big C and Composite-Mesothelioma Testis".Acta Scientific Cancer Biology 9.4 (2025): 01-03.

Copyright

Copyright: © 2025 Anubha Bajaj., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.