Acta Scientific Cancer Biology (ASCB)

Review ArticleVolume 9 Issue 3

Harnessing the Gut Microbiota: Fecal Microbiota Transplantation as a Novel Strategy in Cancer Immunotherapy

Parameshwar Jakinala1, Harikrishna Naik Lavudi1, Nani Babu B1, Doni Sri Lakshmi Angadala2, Athoti revanth2, Kochera Rachel2, Chintakrindi chandra Sekhar2, Anirudh Vivin Sabbi2, Ushasree Ravula1 and Madhumohan Rao Katika1,3*

1Department of Microbiology, Stem Regenex Bio Pvt Ltd, Commercial Complex, Asian Suncity, Hyderabad, Telangana, India
2Department of Biotechnology, Koneru Lakshmaiah Education Foundation Green Fields, Vaddeswaram, Andhra Pradesh, India
3Immunex shield, Sterling Street Irving, Texas, Dallas, USA

*Corresponding Author: Madhumohan Rao Katika, Department of Microbiology, Stem Regenex Bio Pvt Ltd, Commercial Complex, Asian Suncity, Hyderabad, Telangana, India and Immunex shield, Sterling Street Irving, Texas, Dallas, USA.

Received: July 14, 2025; Published: August 18, 2025

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Cancer immunotherapy, particularly immune checkpoint inhibitors (ICIs), faces challenges of resistance and toxicity. The gut microbiota critically influences anti-tumor immunity and ICI efficacy, with dysbiosis linked to carcinogenesis and immunosuppression. Fecal microbiota transplantation (FMT) restores microbial balance, overcoming resistance by enriching immunostimulatory species (e.g., Akkermansia muciniphila and Bifidobacterium etc.) and enhancing CD8⁺ T cell infiltration and dendritic cell activation in melanoma, colorectal, and renal cancers etc. This review, we briefly discuss the potential of FMT in enhancing cancer immunotherapy, providing insights into current research and future directions. Keywords: Fecal Microbiota Transplantation (FMT); Cancer Immunotherapy; Gut Microbiome; Immune Checkpoint Inhibitors (ICIs)

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Citation

Citation: Madhumohan Rao Katika., et al. “Harnessing the Gut Microbiota: Fecal Microbiota Transplantation as a Novel Strategy in Cancer Immunotherapy".Acta Scientific Cancer Biology 9.3 (2025): 43-52.




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