Massiel S Fernández B1*, Eddy Verónica Mora2, Wilfredo Perffeti C3, Daniel Verdecchia3, Medardo Briceño Vergara1 and Emelissa Sosa3
1Cirujano Oncólogo, Policlínica Amado, Maracaibo, Venezuela
2Centro de Investigaciones Médicas y Biotecnológicas de la Universidad de Carabobo (CIMBUC), Servicio de Anatomía Patológica, Instituto de Oncología “Dr. Miguel Pérez Carreño” Valencia, Edo, Carabobo, Venezuela
3Servicio de Cabeza y Cuello, Instituto de Oncología “Dr. Miguel Pérez Carreño” Valencia, Edo, Carabobo, Venezuela
*Corresponding Author: Massiel S Fernández B, Cirujano Oncólogo, Policlínica Amado, Maracaibo, Venezuela.
Received: June 11, 2020; Published: July 23, 2020
Background: The p16INK4a has been identified as a biomarker for lesions caused by HPV, and its presence with Ki-67 immunostains has been proposed as a diagnostic tool for neoplastic pre invasive lesions. Is well known the association between HPV and certain kinds of head and neck squamous cell carcinoma (HNSCC.) The purpose of this study was to determine the use of P16/Ki-67 immunostains in the diagnosis of neoplastic intramucosal pre invasive lesions of head and neck.
Methods: A series 20 biopsies of intramucosal lesions from oral cavity and larynge. We used tissue microarray technique and performed immunostains for P16/Ki-67.
Results: Histological diagnosis was papillomatosis, squamous hyperplasia and dysplasia. Unexpected 60% were female and 40% were man. 13% evolved to a squamous cell carcinoma between 1 month and 5 years. 13% express P16/Ki-67 immunostains. All patients positive Ki-67 evolve to HNSCC.
Conclusion: The series is too short; we were not able to find association between p16/Ki-67 and variables. Data suggests that Ki-67 as biomarker predicting a higher risk of becoming and invasive carcinoma. In addition, the utility of p16 as biomarker of HPV lesions has to be confirm with molecular diagnosis.
Keywords: p16INK4a; HPV; Ki 67; Head and Neck Squamous Carcinoma; Intra Mucosal Lesion; Papillomatosis
Citation: Massiel S Fernández B.,et al. “Expression of P16INK4A and KI 67 in Diagnosis of Head and Neck Intraepithelial Lesions". Acta Scientific Cancer Biology 4.8 (2020): 14-20.
Copyright: © 2020 Massiel S Fernández B.,et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.