Ioannis K Toliopoulos
Konstantinion Research Center of Molecular Medicine and Biotechnology, Thessaloniki, Greece
*Corresponding Author: Ioannis K Toliopoulos, Konstantinion Research Center of Molecular Medicine and Biotechnology, Thessaloniki, Greece.
Received: July 24, 2018; Published: July 31, 2018
Citation: Ioannis K Toliopoulos. “The Role of Antioxidant Substances in the Enhancement of the Immune System against Cancer Cells". Acta Scientific Cancer Biology 2.6 (2018).
The big advantage of the exploration of the molecular and cellular mechanisms of the immune system especially the last two decades opened the door to many innovating and new promising cancer therapies that can save lives and even prevent cancer of any cause. For instance, a variety of cell-based immunotherapies using T cells, NK cells, and dendritic cells have been established and contributed majorly in very useful clinical laboratorial results preventing or even curing cancer .
For many decades, there was a conflict on the scientific community on the use of antioxidants for the treatment against human cancers . However, a yellow colored substance called curcumin has been proven that has antioxidant and anticancer activities . In addition, this herbal supplement has been shown to modulate immune system and especially to help eradicate cancer cells via different immunological mechanisms . Moreover, the antioxidant ascorbic acid (vitamin C) has been demonstrated to play an important role in stimulating the immune system by the natural killer cells (NKCs), which directly kill the cancer cell line k562 . Furthermore, Chang., et al. have shown that administration of resveratrol, a dietary polyphenol compound possessing antioxidant proper-ties at low doses that are nontoxic to immune cells, inhibits lung metastasis of breast cancer tumor . In addition, Toliopoulos., et al. showed the immunomodulating properties of resveratrol on NK cells by a series of experiments, which demonstrated the right concentration of this antioxidant with the maximum capacity of killing of the NK cells against tumor cells .
Copyright: © 2018 Ioannis K Toliopoulos. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.