Zaichick Vladimir¹* and Zaichick Sofia²

¹Radionuclide Diagnostics Department, Medical Radiological Research Centre, Russia
²Laboratory of Dr Gabriela Caraveo Piso, Northwestern University, USA

*Corresponding Author: Zaichick Vladimir, Professor, Radionuclide Diagnostics Department, Medical Radiological Research Centre, Russia.

Received: February 04, 2018; Published: February 13, 2018

Citation: Zaichick Vladimir and Zaichick Sofia. “Significance of Trace Element Quantities in Chondroma and Chondrosarcoma”. Acta Scientific Cancer Biology 2.2 (2018).

Abstract

  To clarify the role of trace elements in the etiology and the pathogenesis of chondroma (ChO) and chondrosarcoma (ChS) of bone, a nondestructive neutron activation analysis with high resolution spectrometry of long-lived radionuclides were performed. The silver (Ag), cobalt (Co), chromium (Cr), iron (Fe), mercury (Hg), rubidium (Rb), antimony (Sb), selenium (Se), and zinc (Zn) mass fraction were measured in three groups of samples: normal bone samples from 27 patients with intact bone (12 females and 15 males), who had died from various non-bone related causes, mainly unexpectedly from trauma, and also in samples, obtained from open biopsies or after operation of 5 patients with chondroma (2 females and 3 males) and 16 patients with chondrosarcoma (3 females and 13 males). The difference in the results between trace element contents in the three groups was evaluated by the parametric Student’s t-test and non-parametric Wilcoxon-Mann-Whitney U-test. In the bone affected by ChO the mean mass fractions of Co, Se, and Zn were significantly higher while the mean mass fraction of Sb was lower than in normal bone tissues. In ChS tissue the mean mass fractions of Co, Fe, and Se were higher while the mean mass fraction of Rb was lower than in normal bone tissues. In ChS tissue the mean mass fractions of Co, Hg and Sb were higher and the mean mass fractions of Rb and Zn were lower than in ChO tissue. Moreover, many correlations between trace elements found in the control group were no longer evident in the neoplastic bone. Thus, considerable changes in trace element content and their relationships were found in chondroma and chondrosarcoma and possible causes and effects of these alterations are discussed.

Keywords: Trace Elements; Human Bone; Chondroma; Chondrosarcoma; Neutron Activation Analysis

Copyright: © 2018 Zaichick Vladimir and Zaichick Sofia. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.