Ahmed Salah¹, Ayman Shehata Dawood²* and Ahmed Saber Soliman¹

¹Department of Obstetrics and Gynecology, Benha University, Benha, Egypt
²Department of Obstetrics and Gynecology, Tanta University, Tanta, Egypt

*Corresponding Author: Ayman Shehata Dawood, Department of Obstetrics and Gynecology, Tanta University, Tanta, Egypt.

Received: June 15, 2026; Published: July 03, 2026

Abstract

Aim: To investigate the effects of PRP on pregnancy rates and endometrial thickness by two different methods.

Patients and methods: Subjects were assigned to either hysteroscopic PRP group where PRP was injected subendometrially under hysteroscopic guidance (n = 50) or intrauterine PRP group where PRP was infused intra-cavitary by ET catheter (n = 73). Clinical pregnancy rates and endometrial thickness were recorded.

Results: Between the two groups, baseline demographic information and cycle features were similar, indicating well-balanced study cohorts. Clinical pregnancy rate was lower in the intrauterine PRP group compared with the Hysteroscopic PRP group (30.1% vs. 60.0%) indicating a superior outcome with the Hysteroscopic approach. BMI remained the only significant predictor of endometrial thickness (95% CI: -0.19 to -0.01, β = -0.10, p = 0.03). Estradiol dose (Dose E2) was not significantly associated with endometrial thickness (95% CI: -0.18 to 0.20, β = 0.01, p = 0.935), nor were PRP route, age, number of embryos transferred, or duration of infertility.

Conclusion: Both routes thickened the endometrium similarly, but hysteroscopic subendometrial injection achieved clinical pregnancy at roughly twice the rate of intrauterine infusion, and the difference held after adjustment.

Keywords: Endometrial Thickness; PRP; Hysteroscopy; Intrauterine Infusion; Pregnancy Rate

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Citation

Citation: Ayman Shehata Dawood., et al. “Intrauterine Infusion Versus Subendometrial Injection of Platelet Rich Plasma in Patients with Thin Endome- trium Before Frozen Embryo transfer". Acta Scientific Women's Health 8.7 (2026): 35-44.

Copyright

Copyright: © 2026 Ayman Shehata Dawood., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.