Kairavi H Gokani¹*, Priyanka H Vora¹, Rana Choudhary¹, Manjusha Ganla¹ and Kedar N Ganla²

¹Consultant, Ankoor Fertility Clinic, Mahim, Mumbai, Maharashtra, India
²Director, Ankoor Fertility Clinic, Mahim, Mumbai, Maharashtra, India

*Corresponding Author: Kairavi H Gokani, Consultant, Ankoor Fertility Clinic, Mahim, Mumbai, Maharashtra, India.

Received: June 12, 2023; Published: June 24, 2025

Abstract

The overall prevalence of insulin resistance among women with PCOS is between 50%-75%. Measurement of 2 hours post 75 grams glucose, serum insulin levels has been shown to correlate with presence of insulin resistance better then HOMA-IR as it is a dynamic test and gives better interpretation of hepatic and peripheral insulin resistance.

Subject and Methods: A Prospective, Single Centre, Observational Study carried for a period of 1 year from January 2023 to December 2023 which included 140 patients. Fasting serum glucose and serum insulin levels and 2 hours post 75 grams glucose, serum glucose and insulin levels were checked in 140 PCOS women in reproductive age group (20-35 years). Correlation between HOMA-IR index and serum insulin levels was done.

Results: In 79% patients, result of post glucose insulin correlated with HOMA-IR. In 17% cases there were raised post glucose insulin.

Conclusion: 2 hours post 75 grams glucose, serum insulin levels can be considered a better parameter to determine presence of insulin resistance as it is a dynamic test and requires only single blood sample. Using this method will help us detect and treat those 17% women which were likely to be missed by doing HOMA-IR.

Keywords: HOMA-IR; Fasting Insulin; Blood Sugar Levels; 2 Hours Post 75 Grams Glucose Serum Insulin; Insulin Resistance; PCOS

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Citation

Citation: Kairavi H Gokani., et al. “A Prospective Observational Study to Determine the Efficacy of 2 Hours Post 75 Grams Glucose Serum Insulin Levels Versus HOMA-IR–for Diagnosing Insulin Resistance in Women with Polycystic Ovarian Syndrome". Acta Scientific Women's Health 7.7 (2025): 23-27.

Copyright

Copyright: © 2025 Kairavi H Gokani., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.