Acta Scientific Women's Health (ASWH)(ISSN: 2582-3205)

Research Article Volume 4 Issue 1

Microbiota of the Vagina

José T Núñez-Troconis*

Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela

*Corresponding Author: José T Núñez-Troconis, Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela.

Received: June 03, 2021; Published: July 26, 2021

Abstract

The objective was to review and analyze the microbiota of the vagina. It was analyzed the composition, the different changes through the women's lives and, its defense mechanism. It was reviewed the websites of Pub Med, Google Scholar, Springer, Web of Knowledge, DOAJ, Hinari, Oxford Academic, JAMA Network, Embase, Research Life for English and Scielo, Lantidex, Imbiomed-L, Redalycy Google Scholar for Spanish. Publications from January 1970 to February 2021. Molecular biology technologies have allowed us to have a better vision of the bacterial diversity present in the vaginal microenvironment or microbiota, as well as have allowed us to discover or reveal the existence of bacterial categories until then unknown.

Keywords: Vagina; Microbiota; Lactobacillus

References

  1. Kalia N., et al. “Microbiota in vaginal health and pathogenesis of recurrent vulvovaginal infections: a critical review”. Annals of Clinical Microbiology and Antimicrobials 19 (2020): 5.
  2. Martin DH. “The microbiota of the vagina and its influence on women's health and disease”. American Journal of the Medical Sciences1 (2012): 2-9.
  3. Farage M and Maibach H. “Lifetime changes in the vulva and vagina”. Archives of Gynecology and Obstetrics 4 (2006): 195-202.
  4. Mendling W. “Normal and abnormal vaginal microbiota”. Journal of Laboratory Medicine4 (2016): 239-246.
  5. Linhares IM., et al. “New findings about vaginal bacterial flora”. Revista da Associacao Medica Brasileira (1992) 56.3 (2010): 370-374.
  6. Dethlefsen L., et al. “An ecological and evolutionary perspective on human-microbe mutualism and disease”. Nature 7164 (2007): 811-818.
  7. Priestley CJ., et al. “What is normal vaginal flora?” Genitourinary Medicine1 (1997): 23-28.
  8. Eschenbach DA., et al. “Effects of vaginal intercourse with and without a condom on vaginal flora and vaginal epithelium”. The Journal of Infectious Diseases 6 (2001): 913-918.
  9. Eschenbach DA., et al. “Influence of the normal menstrual cycle on vaginal tissue, discharge, and microflora”. Clinical Infectious Diseases6 (2000): 901-907.
  10. Gajer P., et al. “Temporal dynamics of the human vaginal microbiota”. Science Translational Medicine132 (2012): 132ra52.
  11. Srinivasan S., et al. “Temporal variability of human vaginal bacteria and relationship with bacterial vaginosis”. PLoS ONE 4 (2010): e10197.
  12. Li J., et al. “Importance of vaginal microbes in reproductive health”. Reproductive Science3 (2012): 235-242.
  13. Ravel J., et al. “Vaginal microbiome of reproductive-age women”. Proceedings of the National Academy of Sciences of the United States of America 108 (2011): 4680-4687.
  14. De Seta F., et al. “The Vaginal Community State Types Microbiome-Immune Network as Key Factor for Bacterial Vaginosis and Aerobic Vaginitis”. Frontiers in Microbiology 10 (2019): 2451.
  15. MacNeill C., et al. “Surfactant protein A, an innate immune factor, is expressed in the vaginal mucosa and is present in vaginal lavage fluid”. Immunology1 (2004): 91-99.
  16. Nunn KL., et al. “Enhanced Trapping of HIV-1 by Human Cervicovaginal Mucus Is Associated with Lactobacillus crispatus-Dominant Microbiota”. mBio5 (2015): e01084-1015.
  17. Arnold K., et al. “Mucosal integrity factors are perturbed during bacterial vaginosis: a proteomic analysis”. AIDS 30 (2014): A30.
  18. Dominguez-Bello MG., et al. “Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns”. Proceedings of the National Academy of Sciences of the United States of America 26 (2010): 11971-11975.
  19. Wylie JG., et al. “Identity and glycogen-fermenting ability of lactobacilli isolated from the vagina of pregnant women”. Journal of Medical Microbiology 3 (1969): 363-366.
  20. Bernbaum JC., et al. “Pilot studies of estrogen-related physical findings in infants”. Environmental Health Perspectives 3 (2008): 416-420.
  21. Alvarez-Olmos MI., et al. “Vaginal lactobacilli in adolescents: presence and relationship to local and systemic immunity, and to bacterial vaginosis”. Sexually Transmitted Diseases 7 (2004): 393-400.
  22. Spear GT., et al. “Human α-amylase present in lower-genital-tract mucosal fluid processes glycogen to support vaginal colonization by Lactobacillus”. Journal of Infectious Diseases 7 (2014): 1019-1028.
  23. O'Hanlon DE., et al. “Vaginal pH and microbicidal lactic acid when lactobacilli dominate the microbiota”. PLoS One11 (2014): e80074.
  24. Keane FE., et al. “A longitudinal study of the vaginal flora over a menstrual cycle”. International Journal of STD and AIDS 8 (1997): 489-494.
  25. Schwebke JR., et al. “Correlation of behaviors with microbiological changes in vaginal flora”. Journal of Infectious Diseases 5 (1999): 1632-1636.
  26. Weinberg ED. “Iron availability and infection”. Biochimica et Biophysica Acta 7 (2009): 600-605.
  27. Hickey RJ., et al. “Vaginal microbiota of adolescent girls prior to the onset of menarche resemble those of reproductive-age women”. mBio 2 (2015): e00097-15.
  28. Zhou X., et al. “Characterization of vaginal microbial communities in adult healthy women using cultivation-independent methods”. Microbiology (Reading) 150 (2004): 2565-2573.
  29. Hyman R., et al. “Microbes on the human vaginal epithelium”. Proceedings of the National Academy of Sciences of the United States of America 102 (2005): 7952-7957.
  30. Reid G., et al. “The rationale for probiotics in female urogenital healthcare”. Medscape General Medicine 1 (2004): 49.
  31. Rogosa M and Sharpe ME. “Species differentiation of human vaginal lactobacilli”. Journal of General Microbiology 23 (1960): 197-201.
  32. Boyd MA., et al. “Comparison of API 50 CH strips to whole-chromosomal DNA probes for identification of Lactobacillus species”. Journal of Clinical Microbiology 4310 (2005): 5309-5311.
  33. Song YL., et al. “Identification of Lactobacillus species of human origin by a commercial kit, API50CHL”. Rinsho Biseibutshu Jinsoku Shindan Kenkyukai Shi2 (1999): 77-82.
  34. Song YL., et al. “Identification of and hydrogen peroxide production by fecal and vaginal lactobacilli isolated from Japanese women and newborn infants”. Journal of Clinical Microbiology9 (1999): 3062-3064.
  35. Vallor AC., et al. “Factors associated with acquisition of, or persistent colonization by, vaginal lactobacilli: role of hydrogen peroxide production”. Journal of Infectious Diseases11 (2001): 1431-1436.
  36. Matsumiya Y., et al. “Molecular epidemiological study of vertical transmission of vaginal Lactobacillus species from mothers to newborn infants in Japanese, by arbitrarily primed polymerase chain reaction”. Journal of Infectious Chemotherapy1 (2002): 43-49.
  37. Pavlova SI., et al. “Genetic diversity of vaginal lactobacilli from women in different countries based on 16S rRNA gene sequences”. Journal of Applied Microbiology3 (2002): 451-459.
  38. Burton JP., et al. “Improved understanding of the bacterial vaginal microbiota of women before and after probiotic instillation”. Applied and Environmental Microbiology1 (2003): 97-101.
  39. Larsen B and Monif GRG. “Understanding the Bacterial Flora of the Female Genital Tract”. Clinical Infectious Diseases 4 (2001): e69-e77.
  40. Chan RC., et al. “Competitive exclusion of uropathogens from human uroepithelial cells by Lactobacillus whole cells and cell wall fragments”. Infectious Immunity1 (1985): 84-89.
  41. Reid G., et al. “Adhesion of three Lactobacillus strains to human urinary and intestinal epithelial cells”. Microbios 302 (1993): 57-65.
  42. Boris S., et al. “Characterization of the aggregation promoting factor from Lactobacillus gasseri, a vaginal isolate”. Journal of Applied Microbiology4 (1997): 413-420.
  43. Boris S and Barbés C. “Role played by lactobacilli in controlling the population of vaginal pathogens”. Microbes Infection5 (2000): 543-546.
  44. Nagy E., et al. “Fibronectin binding of Lactobacillus species isolated from women with and without bacterial vaginosis”. Journal of Medical Microbiology1 (1992): 38-42.
  45. Szöke I., et al. “Binding of extracellular matrix proteins to the surface of anaerobic bacteria”. Journal of Medical Microbiology5 (1996): 338-343.
  46. STEWART-TULL DE. “Evidence that vaginal lactobacillo do not ferment glycogen”. American Journal of Obstetrics and Gynecology 88 (1964): 676-679.
  47. Dellaglio F., et al. “General characteristics of lactic acid bacteria”. En: de Roissart H, Luquet FM, editors. Lactic acid bacteria. Uriag: Lorica (1994): 25-116.
  48. Boskey ER., et al. “Origins of vaginal acidity: high D/L lactate ratio is consistent with bacteria being the primary source”. Human Reproduction9 (2001): 1809-1813.
  49. Nasioudis D., et al. “α-Amylase in Vaginal Fluid: Association With Conditions Favorable to Dominance of Lactobacillus”. Reproductive Sciences11 (2015): 1393-1398.
  50. Hearps AC., et al. “Vaginal lactic acid elicits an anti-inflammatory response from human cervicovaginal epithelial cells and inhibits production of pro-inflammatory mediators associated with HIV acquisition”. Mucosal Immunology6 (2017): 1480-1490.
  51. Wagner W., et al. “L- and D-lactate enhance DNA repair and modulate the resistance of cervical carcinoma cells to anticancer drugs via histone deacetylase inhibition and hydroxycarboxylic acid receptor 1 activation”. Cell Communication and Signaling 13 (2015): 36.
  52. Ñahui Palomino RA., et al. “Vaginal Lactobacillus Inhibits HIV-1 Replication in Human Tissues Ex Vivo”. Frontiers in Microbiology 8 (2017): 906.
  53. Isaacs CE and Xu W. “Theaflavin-3,3'-digallate and lactic acid combinations reduce herpes simplex virus infectivity”. Antimicrobial Agents and Chemotherapy 8 (2013): 3806-3814.
  54. Gong Z., et al. “Lactobacilli inactivate Chlamydia trachomatis through lactic acid but not H2O2”. PLoS One 9 (2014): e107758.
  55. Mossop H., et al. “Influence of lactic acid on endogenous and viral RNA-induced immune mediator production by vaginal epithelial cells”. Obstetics and Gynaecology 4 (2011): 840-846.
  56. Witkin SS., et al. “Lactic acid stimulates interleukin-23 production by peripheral blood mononuclear cells exposed to bacterial lipopolysaccharide”. FEMS Immunology and Medical Microbiology 2 (2011): 153-158.
  57. Ghadimi D., et al. “Lactic acid bacteria enhance autophagic ability of mononuclear phagocytes by increasing Th1 autophagy-promoting cytokine (IFN-gamma) and nitric oxide (NO) levels and reducing Th2 autophagy-restraining cytokines (IL-4 and IL-13) in response to Mycobacterium tuberculosis antigen”. International Immunopharmacology6 (2010): 694-706.
  58. Song YL., et al. “Identification of and hydrogen peroxide production by fecal and vaginal lactobacilli isolated from Japanese women and newborn infants”. Journal of Clinical Microbiology9 (1999): 3062-3064.
  59. Antonio MA., et al. “Colonization of the rectum by Lactobacillus species and decreased risk of bacterial vaginosis”. Journal of Infectious Diseases3 (2005): 394-398.
  60. Vallor AC., et al. “Factors associated with acquisition of, or persistent colonization by, vaginal lactobacilli: role of hydrogen peroxide production”. Journal of Infectious Diseases11 (2001): 1431-1436.
  61. Eschenbach DA., et al. “Prevalence of hydrogen peroxide-producing Lactobacillus species in normal women and women with bacterial vaginosis”. Journal of Clinical Microbiology2 (1989): 251-256.
  62. Hawes SE., et al. “Hydrogen peroxide-producing lactobacilli and acquisition of vaginal infections”. Journal of Infectious Diseases5 (1996): 1058-1063.
  63. St Amant DC., et al. “Inhibition of Neisseria gonorrhoeae by Lactobacillus species that are commonly isolated from the female genital tract”. Infection Immunity12 (2002): 7169-7171.
  64. Klebanoff SJ and Belding ME. “Virucidal activity of H2O2-generating bacteria: requirement for peroxidase and a halide”. Journal of Infectious Diseases3 (1974): 345-348.
  65. Klebanoff SJ and Waltersdorph AM. “Prooxidant activity of transferrin and lactoferrin”. Journal of Experimental Medicine 5 (1990): 1293-1303.
  66. Nes IF., et al. “Biosynthesis of bacteriocins in lactic acid bacteria”. Antonie Van Leeuwenhoek2-4 (1996): 113-128.

Citation

Citation: José T Núñez-Troconis. “Microbiota of the Vagina". Acta Scientific Women's Health 4.1 (2022): 42-52.

Copyright

Copyright: © 2022 José T Núñez-Troconis. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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