Abstract

  The main effects of insulin resistance in the pathogenesis of PCOS, strategies to reduce insulin and improve reproductive parameters in PCOS patients and should be recommended for all overweight and obese patients, and the effects of insulin resistance on the results of IVF or sperm injection were examined. Intracytoplasmic (ICSI) in women with PCOS. Insulin sensitivity was measured by continuous glucose infusion with a form evaluation test (CIGMA). Insulin-resistant (n = 26) and non-insulin-resistant (n = 30) women with PCOS underwent a total of 100 cycles of long-term down-regulation with poserilin acetate, stimulation with recombinant human FSH, and IVF or ICSI. And the ovarian stimulation period for hormone tests. The insulin-resistant and non-insulin-resistant women had similar concentrations of FSH, LH, testosterone, and androstenedione during stimulation, but the insulin-resistant women had hyperinsulinemia and low concentrations of globulin associated with sex hormones. The insulin-resistant women also had low concentrations of estradiol during stimulation and required higher FSH doses, but these differences disappeared after controlling for higher body weight in the insulin-resistant group of women. Insulin resistance was neither associated with hormone levels nor with IVF outcomes. Obesity, regardless of insulin resistance, is associated with relative gonadal resistance, necessary to confirm these findings. In conclusion, it has been shown that reducing insulin resistance improves the ovulation rate in PCOS patients, but there is strong evidence to maintain the usefulness of insulin-causing drugs as a treatment option.

Keywords: Insulin Resistance and PCOS; Obesity and Insulin Resistance; Normal Insulin Sensitivity; Ovarian Stimulation and IVF; Stimulating Hormone and Tests; PCOS; Insulin Sensitivity Recombinant Follicle; Obesity is Associated with Limited Ovulation; AMH in Obese Patients

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Citation

Citation: Mustafa Zakaria., et al. “Duration of the effect of fertility and insulin resistance on IVF or ICSI results in women with PCOS". Acta Scientific Women's Health 2.11 (2020): 55-62.

Copyright

Copyright: © 2020 Mustafa Zakaria., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.