Imran Siddiqui* and Rajiv Jalvi

Head of Audiology at VR Crystal Hearing Solutions Pvt Ltd (Clinics), Thane, Maharashtra, India

*Corresponding Author: I mran Siddiqui, Head of Audiology at VR Crystal Hearing Solutions Pvt Ltd (Clinics), Thane, Maharashtra, India.

Received: December 10, 2025; Published: December 19, 2025

Abstract

Background: Laryngeal squamous cell carcinoma is one of the most common head and neck cancer. Its early detection and diagnosis is essential in order to maximize cure rates and preserve its function. The in vivo diagnosis of benign, pre malignant and early glottic malignant lesions will help in management of the same with preservation of the function of larynx.

Objectives: 1) To study the sensitivity of i-SCAN in early diagnosis of premalignant and malignant glottic lesions. 2) Compare i-SCAN with conventional flexible laryngoscopy in diagnosis of benign, premalignant and malignant glottic lesions.

Methodology: Patient presenting with history of change in voice for greater than 3 weeks underwent flexible laryngoscopy in conventional mode and i-SCAN 1,2,3 modes. The lesions were categorized as benign, suspected malignant and malignant in both the modes. The excision and histopathological examination of the lesions was done. Considering histopathology as gold standard sensitivity of i-SCAN was determined. i-SCAN was compared with flexible laryngoscopy in conventional mode for diagnosis of glottic benign, premalignant and early malignant lesions.

Results: In the study 91.3% patients were male and most common age group was greater than 60 years. The sensitivity of i-SCAN in diagnosis of glottic benign, pre malignant and early malignant lesion is 85%. As compared to flexible laryngoscopy in conventional mode (sensitivity 62%), i-SCAN shows better results in in vivo diagnosis of glottic lesions.

Conclusion: There is a significant correlation of i-SCAN with histopathology for diagnosis of glottic lesions, the sensitivity of i-SCAN for the same being 85%. i-SCAN shows better results than flexible laryngoscopy in conventional mode for in vivo diagnosis of glottic benign, premalignant and early malignant lesions. Keywords:

Keywords: Glottic; i-SCAN; Flexible Laryngoscopy; Histopathology; Benign; Premalignant; Malignant

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Citation

Citation: Shradha Saindani., et al. “Comparative Study Between i-Scan and Conventional Flexible Laryngoscopy in the Diagnosis of Benign and Malignant Laryngeal Lesions".Acta Scientific Otolaryngology 8.1 (2026): 28-36.

Copyright

Copyright: © 2026 Shradha Saindani., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.