Prabu Rajagoapalan¹, Subhendu Nayak², Shyamprasad Kodimule¹ and Raksha Sunhare¹*

¹Development and Research Centre-Probiotics, Vidya Herbs Pvt Ltd, No. 102B & 105B, Pharmaceuticals SEZ Industrial area, KIDB, Hassan, 573201 Karnataka, India
²Vidya USA Corporation, 7 Otis Stone Hunter Road, Bunnell, FL 32100, USA

*Corresponding Author: Raksha Sunhare, Development and Research Centre-Pro- biotics, Vidya Herbs Pvt Ltd, No. 102B & 105B, Pharmaceuticals SEZ Industrial area, KIDB, Hassan, 573201 Karnataka, India.

Received: March 05, 2026; Published: March 31, 2026

Abstract

Recurrent urinary tract infections (UTIs) are a significant therapeutic challenge, particularly for women, necessitating prolonged pharmacological treatment that contributes to antibiotic resistance. Probiotics have recently become more popular as a non-antibiotic choice because of its potential. In this randomized controlled trial, women with a history of recurrent urinary tract infections (rUTIs) were assigned to receive probiotic supplements or a placebo for 90 days. The outcomes measured were the number of symptomatic UTIs, vaginal pH, metabolic indicators, reproductive hormones, stress markers, and inflammatory markers. They also looked at how safe and tolerable it was. Probiotic medication significantly decreased recurrent UTIs (Δ –2.8, p < 0.0001) and vaginal pH (–0.9, p < 0.0001) in comparison to placebo. The lipid profile (total cholesterol, HDL-C), fasting glucose, and CRP all got better. Cortisol levels fell sharply, which means that the HPA axis was not working. There were small changes in the hormones FSH, LH, and estradiol. The adverse events in the probiotic group were less severe and less frequent than those in the placebo group. Probiotic supplementation is a safe and effective method for preventing recurrent urinary tract infections (rUTIs), while also offering additional systemic benefits for metabolism, inflammation, and stress physiology. There is a necessity for more extensive, longitudinal studies.

Keywords: Probiotics; Recurrent Urinary Tract Infections; Vaginal pH; Inflammation; Cortisol; Women’s Health

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Citation

Citation: Raksha Sunhare., et al.“Evaluate the Effectiveness and Safety of Probiotic Blend of Strains on the Clinical and Biological Parameters of Women with Urinary Tract Infection: A Randomized Controlled Study". Acta Scientific Microbiology 9.4 (2026): 12-19.

Copyright

Copyright: © 2026 Raksha Sunhare., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.