Probiotics and Prebiotics: A Comprehensive Review of Their Role in Treating Infectious Diseases and Their Impact on the Gut Microbiome
Ashwini M Bhurre1, NB Hirulkar2* and Bhupesh M Bhendarkar2
1Botany Department, Science Faculty, University of Benghazi, Benghazi, Libya
2Chemistry Department, Science Faculty, University of Benghazi, Benghazi, Libya
3Biology Department Education Faculty, University of Benghazi, Benghazi, Libya
*Corresponding Author: NB Hirulkar, Department of Microbiology, Nabira Mahavidyalaya, Katol, India.
Received:
June 18, 2025; Published: June 21, 2025
Abstract
Prebiotics have a significant effect on the treatment of infectious diseases because they alter the gut flora and boost immunity. Probiotics are advantageous living microorganisms that support the preservation of a healthy stomach environment. Prebiotics are indigestible dietary ingredients that help beneficial bacteria proliferate. The paper looks into the ways that probiotics and prebiotics work, including immune control, the production of antimicrobial chemicals, and pathogen competitive exclusion. They are widely recognized for their ability to treat and prevent gastrointestinal disorders, such as diarrhea and Clostridium difficile infections. Additionally, probiotics may help prevent urinary tract infections, reduce the duration and frequency of respiratory tract infections, and cure skin conditions like atopic dermatitis. Probiotics and prebiotics help fight antibiotic resistance by lowering the demand for antibiotics. Standardizing their use and comprehending strain-specific effects remain difficult despite a plethora of clinical investigations demonstrating their safety and effectiveness. Probiotics and prebiotics may help cure infectious illnesses, but more study is needed to develop specific procedures and regulatory frameworks.
Keywords: Antibiotic Resistance; Infectious Diseases; Prebiotics; Probiotics; Microorganisms
References
- Wiegers C., et al. “Probiotics for the Management of Infectious Diseases: Reviewing the State of the Art”. Frontiers in Microbiology 13 (2022): 877142.
- Kotzampassi K and Giamarellos-Bourboulis EJ. “Probiotics for infectious diseases: more drugs, less dietary supplementation”. International Journal of Antimicrobial Agents4 (2012): 288-296.
- Weichert S., et al. “The role of prebiotics and probiotics in prevention and treatment of childhood infectious diseases”. The Pediatric Infectious Disease Journal8 (2012): 859-862.
- Alvarez-Olmos MI and Oberhelman RA. “Probiotic agents and infectious diseases: a modern perspective on a traditional therapy”. Clinical Infectious Diseases11 (2001): 1567-1576.
- Li X., et al. “Current Status of Probiotics as Supplements in the Prevention and Treatment of Infectious Diseases”. Frontiers in Cellular and Infection Microbiology 12 (2022):
- Olaimat AN., et al. “The potential application of probiotics and prebiotics for the prevention and treatment of COVID-19”. NPJ Science of Food 1 (2020): 17.
- Ng SC., et al. “Mechanisms of action of probiotics: recent advances”. Inflammatory Bowel Diseases2 (2009): 300-310.
- O′ Hara AM and Shanahan F. “Mechanisms of action of probiotics in intestinal diseases”. The Scientific World Journal 1 (2007): 31-46.
- Gogineni VK., et al. “Probiotics: mechanisms of action and clinical applications”. Journal of Probiotics and Health 101 (2013): 2.
- Tomar SK., et al. “Role of probiotics, prebiotics, synbiotics and postbiotics in inhibition of pathogens”. The battle against microbial pathogens: basic science, technological advances and educational programs (2015): 717-732.
- Markowiak P and Śliżewska K. “Effects of probiotics, prebiotics, and synbiotics on human health”. Nutrients 9 (2017): 1021.
- Yeşilyurt N., et al. “Involvement of probiotics and postbiotics in the immune system modulation”. Biologics 2 (2021): 89-110.
- Yadav MK., et al. “Probiotics, prebiotics and synbiotics: Safe options for next-generation therapeutics”. Applied Microbiology and Biotechnology2 (2022): 505-521.
- Raheem A., et al. “Modulatory Effects of Probiotics During Pathogenic Infections With Emphasis on Immune Regulation”. Frontiers in Immunology 12 (2021):
- Lewis SJ and Freedman AR. “The use of biotherapeutic agents in the prevention and treatment of gastrointestinal disease”. Alimentary Pharmacology and Therapeutics9 (1998): 807-822.
- Guandalini S. “Probiotics for prevention and treatment of diarrhea”. Journal of Clinical Gastroenterology 45 (2011): S149-153.
- Bustamante M., et al. “Probiotics and prebiotics potential for the care of skin, female urogenital tract, and respiratory tract”. Folia Microbiologica 65 (2020): 245-264.
- Mortaz E., et al. “Probiotics in the management of lung diseases”. Mediators of Inflammation1 (2013): 751068.
- Strauss M., et al. “Probiotics for the Prevention of Acute Respiratory-Tract Infections in Older People: Systematic Review”. Healthcare 9 (2021):
- Wang F., et al. “A meta-analysis reveals the effectiveness of probiotics and prebiotics against respiratory viral infection”. Bioscience Reports 3 (2021): BSR20203638.
- Schwenger EM., et al. “Probiotics for preventing urinary tract infections in adults and children”. Cochrane Database of Systematic Reviews 12 (2015):
- Venturini S., et al. “The management of recurrent urinary tract infection: non-antibiotic bundle treatment”. Probiotics and Antimicrobial Proteins 16 (2023): 1-9.
- Sihra N., et al. “Nonantibiotic prevention and management of recurrent urinary tract infection”. Nature Reviews Urology12 (2018): 750-776.
- Gupta V., et al. “Recurrent urinary tract infections in women: how promising is the use of probiotics?” Indian Journal of Medical Microbiology3 (2017): 347-354.
- Polak K., et al. “Microbiome Modulation as a Therapeutic Approach in Chronic Skin Diseases”. Biomedicines 9 (2021):
- Habeebuddin M., et al. “Topical Probiotics: More Than a Skin Deep”. Pharmaceutics 14 (2022):
- Knackstedt R., et al. “The role of topical probiotics in skin conditions: A systematic review of animal and human studies and implications for future therapies”. Experimental Dermatology1 (2020): 15-21.
- Mottin VH and Suyenaga ES. “An approach on the potential use of probiotics in the treatment of skin conditions: acne and atopic dermatitis”. International Journal of Dermatology12 (2018): 1425-1432.
- García-Márquez J., et al. “Probiotics for Controlling Infectious Diseases”. Probiotics in Aquaculture 5 (2022): 103-129.
- Liu Y., et al. “Modulation of Gut Microbiota and Immune System by Probiotics, Pre-biotics, and Post-biotics”. Frontiers in Nutrition 8 (2022):
- Eslami M., et al. “Probiotics function and modulation of the immune system in allergic diseases”. Allergologia et Immunopathologia6 (2020): 771-788.
- Lin CS., et al. “Impact of the gut microbiota, prebiotics, and probiotics on human health and disease”. Biomedical Journal5 (2014).
- Van den Nieuwboer M., et al. “The administration of probiotics and synbiotics in immune compromised adults: is it safe?” Beneficial Microbes1 (2015): 3-17.
- Mayes T., et al. “Clinical safety and efficacy of probiotic administration following burn injury”. Journal of Burn Care and Research1 (2015): 92-99.
- Amara AA and Shibl A. “Role of Probiotics in health improvement, infection control and disease treatment and management”. Saudi Pharmaceutical Journal2 (2015): 107-114.
- Vieira AT., et al. “The role of probiotics and prebiotics in inducing gut immunity”. Frontiers in Immunology 4 (2013): 445.
- Jirillo E., et al. “Healthy effects exerted by prebiotics, probiotics, and symbiotics with special reference to their impact on the immune system”. International Journal for Vitamin and Nutrition Research 3 (2012): 200.
- Kelesidis T and Pothoulakis C. “Efficacy and safety of the probiotic Saccharomyces boulardii for the prevention and therapy of gastrointestinal disorders”. Therapeutic Advances in Gastroenterology2 (2012): 111-125.
- Gourbeyre P., et al. “Probiotics, prebiotics, and synbiotics: impact on the gut immune system and allergic reactions”. Journal of Leukocyte Biology5 (2011): 685-695.
- Pilmis B., et al. “Gut Microbiota, Antibiotic Therapy and Antimicrobial Resistance: A Narrative Review”. Microorganisms 2 (2020): 269.
- Arthur C., et al. “Probiotic approach to prevent antibiotic resistance”. Annals of Medicine4 (2016): 246-255.
- Deka B., et al. “Critical Overview of Probiotics Efficacy on Health and its Safety”. Pharmaceutical and Biosciences Journal (2021): 01-15.
- Reid., et al. “New Scientific Paradigms for Probiotics and Prebiotics”. Journal of Clinical Gastroenterology2 (2003): 105-118.
- Boyle RJ., et al. “Probiotic use in clinical practice: what are the risks?” The American Journal of Clinical Nutrition 6 (2006): 1256-1264.
- Hill C., et al. “The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic”. Nature Reviews Gastroenterology and Hepatology 11 (2014): 506-514.
- Hempel S., et al. “Probiotics for the Prevention and Treatment of Antibiotic-Associated Diarrhea: A Systematic Review and Meta-analysis”. JAMA 18 (2012): 1959-1969.
- Sanders ME., et al. “Probiotics and prebiotics in intestinal health and disease: from biology to the clinic”. Nature Reviews Gastroenterology and Hepatology 16 (2019): 605-616.
- McFarland LV. “Deciphering the role of the microbiome in clostridium difficile disease: progress and challenges”. Genome Medicine 1 (2018): 52.
- Goldenberg JZ., et al. “Probiotics to Prevent Clostridium difficile Infection in Patients Receiving Antibiotics”. JAMA 5 (2018): 499-500.
- Ouwehand AC., et al. “Probiotics: an overview of beneficial effects. In: Siezen, R.J., Kok, J., Abee, T., Schasfsma, G. (eds) Lactic Acid Bacteria: Genetics, Metabolism and Applications. Springer, Dordrecht (2002).
- Mary Ellen Sanders. “Probiotics: Definition, Sources, Selection, and Uses”. Clinical Infectious Diseases2 (2008): S58-S61.
- Marco ML and Tachon S. “Environmental factors influencing the efficacy of probiotic bacteria”. Current Opinion in Biotechnology2 (2013): 207-213.
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