Sana A Pathan¹ and NB Hirulkar² *

¹ Department of Molecular Biology and Genetics, R.T.M.N.U Nagpur University, Nagpur M.S., India
²Department of Microbiology, Nabira Mahavidyalaya, Katol 441302 M.S., India

*Corresponding Author: NB Hirulkar, Department of Microbiology, Nabira Mahavidyalaya, Katol 441302 M.S., India.

Received: June 18, 2025; Published: June 28, 2025

Abstract

A biofilm is a group of microorganisms that adheres securely to inanimate or living surfaces and is encased in an extracellular polymeric matrix or self-generated substance. Chronic wound infections have a major clinical and financial impact on people all over the world. They also have a big impact on healthcare systems and the lives of those who are impacted. With a focus on important topics like the pathophysiology of biofilm growth and the clinical implications of biofilms in chronic infections, this review aims to provide a thorough examination of biofilm formation in chronic illnesses. Methicillin-resistant Staphylococcus aureus (MRSA), Coagulase-negative staphylococci (CoNS), and multidrug-resistant Gram-negative bacilli, including Metallo Beta-Lactamase (MBL), AmpC Beta-Lactamase, and Extended Spectrum Beta-Lactamase (ESBL), as well as mechanisms like efflux and porin deficiency, are among the multidrug-resistant organisms that are becoming more prevalent in these areas. Biofilms pose a significant challenge to modern healthcare and are a substantial contributor to the chronicity, persistence, and resistance to treatment of wound infections. Their multi layered structure, which is maintained by a protective extracellular matrix, slows down the immune system and antimicrobial penetration, which prolongs healing, increases patient morbidity, and raises health care costs.

Keywords: Biofilm; Chronic Wound Infections; Multidrug-Resistant Organisms and Health Care

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Citation

Citation: Sana A Pathan and NB Hirulkar. “The Role of Biofilm in Antibiotic Resistance and Chronic Wound Infections of Patients".Acta Scientific Microbiology 8.7 (2025): 29-37.

Copyright

Copyright: © 2025 Sana A Pathan and NB Hirulkar. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.