Hanan K Bokhamada¹, Hind A Elzletni¹*, Intesar Ahmad Hasan Elmasli¹, Fatma M Elmestiri², Fathia A Halom¹ and Aida Mohamed Mahmoud¹

¹Biology Department, Faculty of Education, University of Benghazi, Benghazi, Libya
²Zoology Department, Science Faculty, University of Benghazi, Benghazi, Libya

*Corresponding Author: Hind A Elzletni, Zoology Department, Science Faculty, University of Benghazi, Benghazi, Libya.

Received: April 14, 2025; Published: April 23, 2025

Abstract

Background: Obesity has become main public health concerns globally. The main player in development of obesity that has been pointed out for two decades is the gut bacteria. Alteration in gut bacteria structure is associated with obesity development.

Aim, our study aimed to identify differences in gut bacteria structures between obese and non-obese subject. Besides, to determine whether there is correlation between fecal gut bacteria and anthropometric measurements, FSB, HbA1and lipid profile. Methods: the fecal microbiota of 61 Libyan volunteers was observed using conventional culture method.

Results: significant decreased was detected in prevalence of Prevotella copri (p. copri) in obese subject comparing to non- obese. The abundance of P. copri negatively correlated with age (r = -0.529, p = 0.001), BMI (r = -0.580, p = 0.0003), TC (r = -0.47, p = 0.001), LDL-C (r = -0.320, p = 0.05), and HDL-C (r = -0.409, p = 0.02) and positively correlated with WC (r = 0.501, p = 0.003).

Conclusion: P. copri was significantly less prevalent in obese individuals suggests its beneficial effects on BMI and lipid metabolism. This was confirmed by the negative correlation between P. copri and BMI, LDL, and HDL. The age-related decline in P. copri further exacerbates these metabolic disturbances. However, its positive correlation with WC may reflect a more nuanced relationship with fat distribution, particularly abdominal fat. This highlights the complexity of the gut microbiome's role in metabolic health and obesity, where different bacterial species can have distinct, sometimes opposing, effects on various metabolic parameters

Keywords: Obesity; Fecal Gut Bacteria; BMI; FBS; Lipid Profile

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Citation

Citation: Hind A Elzletni., et al. “Comparison of Gut Bacteria Structures Between Obese and Non-Obese Subjects in Libya".Acta Scientific Microbiology 8.5 (2025): 74-81.

Copyright

Copyright: © 2025 Hind A Elzletni., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.