Abstract

Background: Methicillin resistance in Staphylococcus aureus is associated with multi drug resistance. In hospitals and community mortality and morbidity rate increases due to MRSA. Methicillin resistant Staphylococcus aureus (MRSA) results in serious complications. Methicillin sensitive strains are less problematic than MRSA.

Aim: To study the changing trends in resistance patterns of MRSA.

Materials and Methods: Fifty eight clinical isolates of MRSA which were obtained in 2017 - 2020 were identified by using Cefoxitin disc according to CLSI guidelines.

Results: MRSA isolates showed high resistance to ciprofloxacin, gentamicin in comparison with other drugs. Sensitivity to Vancomycin and Linezolid was 100%. Recently resistance among MRSA has increased for most antibiotics.

Conclusion: As the rate of drug resistance in MRSA is increasing, resistance should be evaluated after a period of time and antibiotic therapy should be guided accordingly.

Keywords: Methicillin Resistant Staphylococcus aureus; Multi Drug Resistance; Cefoxitin

References

1. Arunava S., et al. “Changing Trends in Resistance pateern of methicillin resistant Staphylococcus aureus”. Journal of Clinical and Diagnostic Research9 (2013): 1979-1982.
2. Bhatt MJ., et al. “Antimicrobial susceptibility profile of methicillin-resistant Staphylococcus aureus at a tertiary care centre”. Archives of Clinical Microbiology 6 (2015): 3-6.
3. Shanson DC., et al. “Outbreak of hospital infection with a strain of Staphylococcus aureus resistant to gentamicin and methicillin”. Lancet 2 (1976): 1347-1348.
4. SR More., et al. “Changing trends in resistance pattern of methicillin resistant Staphylococcus aureus in burn patients”. International Journal of Current Microbiology and Applied Sciences 1 (2019) 22-27.
5. Pantosti A and Venditti M. “What is MRSA?” European Respiratory Journal 34 (2009): 1190-1196.
6. Pavillard R., et al. “Epidemic of hospital-acquired infection due to methicillin-resistant Staphylococcus aureus in major Victorian hospitals”. Medical Journal of Australia 1 (1985): 451-455.
7. Simor AE., et al. “Antimicrobial susceptibilities of health care-associated and community associated strains of methicillin-resistant Staphylococcus aureus from hospitalized patients in Canada, 1995 to 2008”. Antimicrobial Agents and Chemotherapy 54 (2010): 2265-2268.
8. Srinivasan S., et al. “Risk factors and associated problems in the management of infections with methicillin resistant Staphylococcus aureus”. Indian Journal of Medical Microbiology 2006 24 (2006): 182-185
9. Kumar S., et al. “Prevalence and current antibiogram of staphylococci isolated from various clinical specimens in a tertiary care hospital in Pondicherry”. The Internet Journal of Microbiology 10 (2010).
10. Verma S., et al. “Growing problem of methicillin resistant staphylococci –Indian scenario”. Indian Journal of Medical Science 54 (2000): 535-540.
11. Indian Network for Surveillance of Antimicrobial Resistance group, India. “Methicillin resistant Staphylococcus aureus (MRSA) in India: Prevalence and susceptibility pattern”. Indian Journal of Medical Research 137 (2019): 363-369.
12. Kasten MJ. “Clindamycin, metronidazole, and chloramphenicol”. Mayo Clinic Proceedings 74 (1999): 825-833.
13. Ruebner R., et al. “The complications of the central venous catheters which were used for the treatment of acute hematogenous osteomyelitis”. Pediatrics 117 (2006): 1210-1215.
14. Fiebelkorn KR., et al. “The practical disc diffusion method for the detection of inducible clindamycin resistance in Staphylococcus aureus and coagulase negative Staphylococcus”. Journal of Clinical Microbiology 41 (2003): 4740-4744.
15. Danzmann L., et al. “Health care workers causing large nosocomial outbreaks: a systematic review”. BMC Infection Disease1 (2013): 98.
16. European Centre for Disease Prevention and Control/European Medicines Agency (ECDC/EMEA). Joint technical report The bacterial challenge: time to react. Stockholm: ECDC/EMEA 2009.
17. Sarma JB and Ahmed GU. “Characterisation of methicillin resistant aureus strains and risk factors for acquisition in a teaching hospital in northeast India”. Indian Journal of Medical Microbiology 28 (2010): 127-129.
18. Lafaurie M., et al. “Reduction of fluoroquinolone use is associated with a decrease in methicillin-resistant Staphylococcus aureus and fluoroquinolone-resistant Pseudomonas aeruginosa isolation rates: a 10 year study”. Journal of Antimicrobial Chemotherapy 67 (2012): 1010-105.
19. Thind P., et al. “Bacteriological profile of community-acquired pyodermas with special reference to methicillin resistant Staphylococcus aureus”. Indian Journal of Dermatology, Venereology and Leprology 76 (2010): 572-574.
20. Anupurba S., et al. “Prevalence of methicillin resistant Staphylococcus aureus in a tertiary referral hospital in eastern Uttar Pradesh”. Indian Journal of Medical Microbiology 21 (2003): 49-51.
21. Vidhani S., et al. “Study of methicillin resistant aureus (MRSA) isolates from high risk patients”. Indian Journal of Medical Microbiology 9 (2001): 13-16.
22. Shenoy MS., et al. “Significance of MRSA strains in community associated skin and soft tissue infections”. Indian Journal of Medical Microbiology 28 (2010): 152-154.
23. Saikia L., et al. “Prevalence and antimicrobial susceptibility pattern of methicillin-resistant Staphylococcus aureus in Assam”. Indian Journal of Critical Care Medicine 13 (2009): 156-158.
24. Deep A., et al. “Quinpristin dalfopristin resistance in gram Positive bacteria: Experience from a tertiary care referral center in North India”. Journal of Infectious Diseases and Antimicrobial Agents 25 (2008): 117-121.

Citation

Citation: Ambreen Shafaat Khan., et al. “Changing Patterns of Methicillin-Resistant Staphylococcus aureus in a Tertiary Care Hospital". Acta Scientific Microbiology 3.9 (2020): 03-07.

Copyright

Copyright: © 2020 Ambreen Shafaat Khan., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.