Craig A Ahern*

Concordia University, Chicago, Waukegan, Chicago

*Corresponding Author: Craig A Ahern, Concordia University, Chicago, Waukegan, Chicago.

Received: June 03, 2025; Published:June 26, 2025

Abstract

Background: Ankylosing Spondylitis (AS) often involves gastrointestinal (GI) symptoms that may not always be linked to inflammatory bowel disease. Illness Anxiety Disorder (IAD) can worsen symptom perception and reduce quality of life.

Objective: To assess the prevalence of IAD in AS patients with GI symptoms and explore its mediating role between GI symptoms and quality of life.

Methods: Two hundred AS patients completed the Health Anxiety Inventory (HAI), GI Symptom Rating Scale (GSRS), and AS Quality of Life questionnaire (ASQoL). Statistical analyses included correlation, regression, and mediation modeling.

Results: GI symptoms were present in 61% of patients, with 34% meeting IAD criteria. IAD severity correlated strongly with GI symptom burden (r = 0.47) and reduced quality of life (r = -0.52). Mediation analysis showed IAD partially mediates the effect of GI symptoms on quality of life (indirect effect β = -0.19).

Conclusion: Illness anxiety significantly contributes to perceived GI symptom burden and poor quality of life in AS. Integrated psychological screening is recommended.