Acta Scientific Gastrointestinal Disorders

Case Report Volume 8 Issue 3

Short Case Report: Ulcerative Exfoliative Esophagitis Induced by Dabigatran

Rakesh Kumar Jagdish1* and Harsh Kapoor2

1Senior Consultant, Department of Gastroenterology, Hepatobiliary and Liver Transplant, Metro Hospital, India
2Chairman, Department of Gastroenterology, Hepatobiliary and Liver Transplant, Metro Hospital, India

*Corresponding Author: Rakesh Kumar Jagdish, Department of Gastroenterology, Hepatobiliary and Liver Transplant, Metro group of Hospitals, Delhi and NCR, India.

Received: February 10, 2025; Published: February 23, 2025

Abstract

A 66-year-old woman with chronic atrial fibrillation, coronary artery disease, and left ventricular dysfunction, presented with gastrointestinal bleeding and respiratory distress. She was hemodynamically unstable, leading to immediate blood transfusions and treatment with pantoprazole infusion and antibiotics. She was on dabigatran 150 mg, since last 2 years and aspirin 75 mg, her 2 D echocardiography showed left ventricular dysfunction with LVEF 40-45%. An upper GI endoscopy revealed ulcerative exfoliative esophagitis, potentially linked to dabigatran use (Image 1-4).

Keywords: Cardiology; Pulmonology

References

  1. Connolly SJ., et al. "Dabigatran versus warfarin in patients with atrial fibrillation”. New England Journal of Medicine12 (2009): 1139-1151.
  2. Schulman S., et al. "Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients”. Journal of Thrombosis and Haemostasis4 (2005): 692-694.
  3. Toyomasu Y., et al. "Mechanisms of esophageal mucosal injury caused by various medications”. World Journal of Gastrointestinal Pharmacology and Therapeutics3 (2014): 100-105.
  4. Gonzalez JM and Lichtenberger LM. "Ulcerative and exfoliative esophagitis secondary to dabigatran”. Endoscopy International Open2 (2010): E106-E110.
  5. Strand DS., et al. "25 years of proton pump inhibitors: a comprehensive review”. Gut and Liver 1 (2017): 27-37.
  6. Abraham NS., et al. "Comparative risk of gastrointestinal bleeding with direct oral anticoagulants”. Gastroenterology1 (2020): 69-81.
  7. Katz PO., et al. "Guidelines for the diagnosis and management of gastroesophageal reflux disease”. American Journal of Gastroenterology3 (2013): 308-328.

Citation

Citation: Rakesh Kumar Jagdish and Harsh Kapoor. “Short Case Report: Ulcerative Exfoliative Esophagitis Induced by Dabigatran".Acta Scientific Gastrointestinal Disorders 8.3 (2025): 22-24.

Copyright

Copyright: © 2025 Rakesh Kumar Jagdish and Harsh Kapoor. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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