Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Case Report Volume 7 Issue 4

Elevated Cobalamin as Initial Presentation of Colon Cancer: Case Report

Karam Karam1, Johny Salem2, Houssein Chebbo3, Sarah Saleh3, Georges El Hachem4 and Noha Al-Hachem1*

1Associate Professor in Department of Gastroenterology, Faculty of Medicine, University of Balamand, Dekweneh-Beirut, Lebanon
2Department of Internal Medicine, Faculty of Medicine, University of Balamand, Dekweneh-Beirut, Lebanon
3Department of Gastroenterology, Faculty of Medicine, University of Balamand, Dekweneh-Beirut, Lebanon, Beirut, Lebanon
4Faculty of Medicine, University of Balamand, Dekweneh-Beirut, Lebanon

*Corresponding Author: Noha Al-Hachem, Associate Professor in Department of Gastroenterology, Faculty of Medicine, University of Balamand, Dekweneh-Beirut, Lebanon.

Received: March 18, 2024; Published: March 30, 2024


Introduction: Globally, colorectal cancer (CRC) is the third-most common type of cancer. It is imperative to find early markers for the prompt detection of CRC, as the prognosis is highly dependent on the stage at which the cancer is identified. Hypercobalaminemia, or high serum levels of Vitamin B12, is a frequently underestimated abnormality in clinical practice. A potential correlation between high vitamin B12 levels and tumorigenesis has been reported. This article reports an additional case where isolated elevation of cobalamin leads to the subsequent diagnosis of colorectal cancer.

Case: 42-year-old Lebanese female with no past medical or surgical history presenting for a regular checkup and was found to have incidental elevated vitamin b12 on general health maintenance laboratory examination. Further investigations lead to the early diagnosis of colon cancer and to favorable outcomes post resection.

Discussion: Despite the existence of effective screening techniques, nearly 2 million cases were reported in 2022, with more than 900,000 deaths per year. Vitamin B12 is essential in homocysteine metabolism, acting as a cofactor of the methionine synthetase enzyme. Due to its significant involvement in DNA methylation, this enzyme may promote tumorigenesis in colorectal cancer and might be a potential non-invasive screening marker as reflected by this case.

Conclusion: Colorectal cancer can present with multiple symptoms, most commonly weight loss, altered bowel habits, or rectal bleeding. Less frequently, it can present as an isolated elevation in vitamin B12 or cobalamin. Clinicians should therefore suspect malignancy, especially CRC, in cases presenting with elevated cobalamin.

Keywords: Cobalamin; Vitamin B12; Colon Cancer


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Citation: Noha Al-Hachem., et al. “Overview of Natural Faming-A New Environmentally Responsible Production System". Acta Scientific Gastrointestinal Disorders 7.4 (2024): 27-30.


Copyright: © 2024 Noha Al-Hachem., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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