Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Case Report Volume 7 Issue 1

Primary Hyperparathyroidism in Biopsy-Defined Adult Celiac Disease

Hugh James Freeman*

Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, British Columbia, Canada

*Corresponding Author: Hugh James Freeman, Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, British Columbia, Canada.

Received: November 06, 2023; Published: December 08, 2023


Osteoporosis and secondary hyperparathyroidism commonly occur in celiac disease thought to be mainly due to impaired intestinal calcium and vitamin absorption. A 41-yr-old female diagnosed with celiac disease and osteoporosis in 1979 was on a life-long gluten-free diet. In 1997, she developed abdominal pain. Blood and abdominal imaging studies (ultrasound, CT and barium studies) were normal, except for a slightly elevated serum calcium level. Endoscopic studies showed rare gastric and duodenal bulbar erosions that responded initially to courses of ranitidine, and later, omeprazole. Serum gastrins were normal. Duodenal biopsies were normal with healed celiac disease. Later, serum calcium progressively increased with a rising parathyroid hormone (PTH) levels.
Primary hyperparathyroidism was suspected and, in 2001, neck dissection showed a parathyroid gland adenoma that was resected. This completely resolved her prior persistent hypercalcemia and abdominal pain. Primary hyperparathyroidism due to a parathyroid adenoma is rare in celiac disease but may cause osteopenic bone disease, recurrent bouts of abdominal pain and mucosal erosions responsive to anti-secretory agents.

Keywords: Primary Hyperparathyroidism; Biopsy; Adult Celiac Disease


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Citation: Hugh James Freeman. “Primary Hyperparathyroidism in Biopsy-Defined Adult Celiac Disease".Acta Scientific Gastrointestinal Disorders 7.1 (2024): 10-12.


Copyright: © 2024 Hugh James Freeman. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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