Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Research Article Volume 6 Issue 12

The Effect of C. Papaya Leaf Powder on Biochemical and Haematological Parameters in Normal Rats.

Murali Adiga*

Lecturer, Department of Physiology, KMC, MAHE, Manipal

*Corresponding Author: Murali Adiga, Lecturer, Department of Physiology, KMC, MAHE, Manipal.

Received: November 10, 2023; Published: November 27, 2023

Abstract

Dengue fever is a mosquito-borne illness characterized by severe reduction in the platelet count. Since it is a viral disease, there is no single best treatment available currently. Some studies shown that Papaya extract may help Dengue patients by improving platelet counts. Recently, there is a increase in trend of consuming Papaya juice or tablets regularly.

Therefore, we would to like to see the long-term impact (beneficial or adverse) of Papaya powder diet on liver and kidney parameters in normal rats. Normal male wistar rats will be regularly fed with 0%, 10% and 20% Papaya diet for 90 days. After 90 days, blood was collected by retro-orbital puncture and analysed for haemoglobin, PCV, RBC count, WBC count, platelet count, Fasting glucose, AST, ALT, Urea, Creatinine, total cholesterol triglycerides. Our results shown significant increase in haemoglobin, PCV and platelet counts in Papaya diet groups compared to control group. But, there is no significant changes in any of the biochemical parameters. This proves the erythropoietic and thrombopoietic properties of the Papaya powder in normal rats. Also proves that Papaya powder has no adverse effect on liver and kidney in normal healthy rats when consumed for longer period.

Keywords: Carica Papaya; Dengue Fever; Platelets

References

  1. Jha DN. “Doctors Unsure but Papaya a Hit for Dengue Treatment”. The Times of India (2015).
  2. Sarala N and Paknikar S. “Papaya extract to treat dengue: A novel therapeutic option?” Annals of Medical and Health Science Research 4 (2014): 320-324.
  3. Subenthiran , et al. “Carica papaya leaves juice significantly accelerates the rate of increase in platelet count among patients with dengue fever and dengue haemorrhagic fever”. Evidence-Based Complementary and Alternative Medicine 2013 (2013): 616737.
  4. Senthilvel , et al. “Flavonoid from Carica papaya inhibits NS2B-NS3 protease and prevents dengue 2 viral assembly”. Bioinformation 9 (2013): 889-895.
  5. Dharmarathna SL., et al. “Does Carica papaya leaf-extract increase the platelet count? An experimental study in a murine model”. Asian Pacific Journal of Tropical Biomedicine 3 (2013): 720-724.
  6. OJ Sule., et al. “Effect of Carica papaya (L) Leaves on Haematological Parameters in Ccl4-induced Wistar Albino Rats”. BJMMR3 (2016): 1-6.
  7. Juárez-Rojop., et al. “Hypoglycemic effect of Carica papaya leaves in streptozotocin- induced diabetic rats”. BMC Complementary and Alternative Medicine 12 (2012): 236.

Citation

Citation: Murali Adiga. “The Effect of C. Papaya Leaf Powder on Biochemical and Haematological Parameters in Normal Rats".Acta Scientific Gastrointestinal Disorders 6.12 (2023): 66-69.

Copyright

Copyright: © 2023 Murali Adiga. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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Acceptance rate35%
Acceptance to publication20-30 days

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