Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Research Article Volume 6 Issue 11

The Role of Cholinergic Receptors in the Implementation of the Stimulating Effect of Serotonin on the Stomach

VM Smirnov1*, DS Sveshnikov2 and AV Kuchuk3

1Doctor of Biological Sciences, Professor, Department of Physiology, Pirogov Russian National Research Medical University (RNRMU), Moscow, Russia
2Doctor of Medical Sciences, Professor, Department of Physiology, Peoples' Friendship University of Russia (RUDN), Moscow, Russia
3Ph.D., Assistant of the Department of Anatomy, RUDN University, Moscow, Russia

*Corresponding Author: VM Smirnov; Doctor of Biological Sciences, Professor, Department of Physiology, Pirogov Russian National Research Medical University (RNRMU), Moscow, Russia.

Received: April 27, 2023; Published: October 04, 2023


The aim of the study: Was to elucidate the role of cholinergic receptors in the stimulating effect of serotonin on gastric motility.

Materials and methods: The studies were performed on sexually mature Wistar rats on an empty stomach under the conditions of the whole organism in the surgical stage of anesthesia (nembutal, 60 mg/kg intramuscularly). The electromyogram and hydrostaticpressure in the gastric cavity were recorded using the BioAmp ML132 amplifier (Adinstruments, Australia), the Maclab 8e analog-to-digital converter (Adinstruments, Australia), the Macintosh Performa 6400/180 computer and the Chart 4.2.3 program.

Results and Discussion: It was found that the preliminary blockade of N-choli noreceptors leads to an increase in the stimulating effect of the stomach on the introduction of serotonin by 40%, in conditions of blockade of M-cholinergic receptors - by 56%. The blockade of N-cholinergic receptors itself increased the strength of gastric contractions by 32%, while a separate blockade of M-cholinergic receptors was not accompanied by a change in the strength of gastric contractions.

Conclusion: The weakening of the stimulating effect of serotonin on gastric motility with the help of N- and M-cholinergic receptors is carried out through the activation of adrengic and VIPergic inhibitory neurons.

Keywords: Stomach; Motility; Serotonin; M- and N-cholinergic receptors


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Citation: VM Smirnov., et al. “The Role of Cholinergic Receptors in the Implementation of the Stimulating Effect of Serotonin on the Stomach".Acta Scientific Gastrointestinal Disorders 6.11 (2023): 03-07.


Copyright: © 2023 VM Smirnov., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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