Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Research Article Volume 6 Issue 8

Comparing Mean Duration of Post-operative Analgesia in Laparoscopic Cholecystectomy Patients Receiving Intra-peritoneal Bupivacaine/Bupivacaine Plus Buprenorphine

Muhammad Bilal Akbar*, Babar Hameed, Keesa Zahra

General Surgery, NHS Grampian De Grays Hospital, United Kingdom

*Corresponding Author: Muhammad Bilal Akbar, General Surgery, NHS Grampian De Grays Hospital, United Kingdom.

Received: June 27, 2023; Published: July 18, 2023

Abstract

Laparoscopic procedures are the newest techniques with better outcomes for most upper GI pathologies. As a matter of fact Laparoscopic Cholecystectomy has become the gold standard these days for cholelithiasis. In post op recovery for these patients, Post-operative pain is one of the commonest entity to deal with and there are number of drugs that can be added. Bupivacaine and Buprenorphine have shown promising results.

Objective: To compare the mean duration of post-operative analgesia in laparoscopic cholecystectomy patients receiving intra-peritoneal bupivacaine/bupivacaine plus buprenorphine.

Study design: Randomized controlled trial.

Settings: Surgical department, National Hospital, and medical Centre, Lahore.

Duration of study; 24-02-20to 24-09-20.

Sampling technique: Non probability consecutive sampling.

Methodology: In this study the patients of both sex groups with age in the range of 20 to 60 years undergoing laparoscopic cholecystectomy were included. Cases in group A were given Bupivacaine 0.25% and those in group B were given Bupivacaine 0.25% and Buprenorphine. Duration of post operative analgesia was noted.

Results: In this study there were total 60 cases, 30 in each group. There were 14 (46.67%) males in group A and 13 (43.33%) in group B with mean age in group A was 45.67 ± 11.12 vs 44.89 ± 9.66 in group B. Mean duration of post operative analgesia was 3.14 ± 0.71 vs 8.97 ± 1.13 in group A and B with p = 0.001. Mean duration of post operative analgesia in males was 3.19 ± 0.81 vs 9.02 ± 0.91 and in females 3.02 ± 0.67 vs 8,34 ± 0.56 in group A and B with p values of 0.001 and 0.003 respectively. This duration of analgesia was also significantly high in both age groups i.e. 20-39 years and 40-60 years with p values of 0.001 and 0.002 respectively. Post operative analgesia duration was much better in group B regarding BMI less than 30 where this was seen as 9.97 ± 1.23 vs 3.87 ± 1.13 with p = 0.001 and in BMI 30 or more this was 8.11 ± 0.94 vs 2.97 ± 0.43 in group B and A respectively with p = 0.01.

Conclusion: Mean duration of post operative analgesia was significantly better in cases treated with intra peritoneal bupivacaine and buprenorphine as compared to bupivacaine only and this difference is significantly better in all the confounding variable like age, gender and BMI.

 Keywords: Bupivacaine; Buprenorphine; VAS

References

  1. Litwin DE and Cahan MA. “Laparoscopic cholecystectomy”. Surgical Clinics of North America6 (2008): 1295-1313.
  2. National Institutes of Health (NIH). “Gallstones and Laparoscopic Cholecystectomy”. NIH Consensus Statement. NIH. September 14-16 (1992).
  3. Calland JF., et al. “Outpatient laparoscopic cholecystectomy: patient outcomes after implementation of a clinical pathway”. Annals of Surgery5 (2001): 704-715.
  4. Shea JA., et al. “Indications for and outcomes of cholecystectomy: a comparison of the pre and postlaparoscopic eras”. Annals of Surgery3 (1998): 343-350.
  5. Nealon WH., et al. “Appropriate timing of cholecystectomy in patients who present with moderate to severe gallstone-associated acute pancreatitis with peripancreatic fluid collections”. Annals of Surgery6 (2004): 741-749; discussion 749-751.
  6. Lillemoe KD., et al. “Laparoscopic cholecystectomy as a "true" outpatient procedure: initial experience in 130 consecutive patients”. Journal of Gastrointestinal Surgery1 (1999): 44-49.
  7. McSherry CK. “Cholecystectomy: the gold standard”. American Journal of Surgery3 (1989): 174-178.
  8. Potts JR. “What are the indications for cholecystectomy?”. Cleveland Clinic Journal of Medicine1 (1990): 40-47.
  9. Gupta SK and Shukla VK. “Silent gallstones: a therapeutic dilemma”. Tropical Gastroenterology2 (2004): 65-68.
  10. Pejic MA and Milic DJ. “[Surgical treatment of polypoid lesions of gallbladder]”. Srpski Arhiv Za Celokupno Lekarstvo 7-8 (2007): 319-324.
  11. Tucker ON., et al. “Is concomitant cholecystectomy necessary in obese patients undergoing laparoscopic gastric bypass surgery?”. Surgical Endoscopy11 (2008): 2450-2454.
  12. Hunter JG. “Acute cholecystitis revisited: get it while it's hot”. Annals of Surgery4 (1998): 468-469.
  13. Lo CM., et al. “Prospective randomized study of early versus delayed laparoscopic cholecystectomy for acute cholecystitis”. Annals of Surgery4 (1998): 461-467.
  14. Willsher PC., et al. “Early laparoscopic cholecystectomy for acute cholecystitis: a safe procedure”. Journal of Gastrointestinal Surgery1 (1999): 50-53.
  15. Pessaux P., et al. “Laparoscopic cholecystectomy in acute cholecystitis. A prospective comparative study in patients with acute vs. chronic cholecystitis”. Surgical Endoscopy4 (2000): 358-361.
  16. Adams DB. “The importance of extrahepatic biliary anatomy in preventing complications at laparoscopic cholecystectomy”. Surgical Clinics of North America4 (1993): 861-871.

Citation

Citation: Muhammad Bilal Akbar., et al. “Comparing Mean Duration of Post-operative Analgesia in Laparoscopic Cholecystectomy Patients Receiving Intra-peritoneal Bupivacaine/Bupivacaine Plus Buprenorphine". Acta Scientific Gastrointestinal Disorders 6.8 (2023): 20-25.

Copyright

Copyright: © 2023 Muhammad Bilal Akbar., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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