Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Case Report Volume 6 Issue 4

Myelodysplastic Syndrome Mimicking Thrombotic Thrombocytopenic Purpura Treated with Allogeneic Bone Marrow Transplantation

Deniz Granit1*, Turgay Ulas2 and Mehmet Sinan Dal3

1Near East Hospital, School of Medicine, Department of Internal Medicine, Nicosia, Cyprus

2Near East Hospital, School of Medicine, Department of Internal Medicine, Division of Hematology, Nicosia, Cyprus

3Ankara Oncology Hospital, University of Health Science, Department of Internal Medicine, Division of Hematology, Ankara, Turkey

*Corresponding Author: Deniz Granit, Near East Hospital, School of Medicine, Department of Internal Medicine, Nicosia, Cyprus.

Received: March 09, 2023; Published: March 20, 2023

Abstract

Myelodysplastic syndrome(s) (MDS) are a group of hemopoietic stem-cell disorders characterized by ineffective hematopoiesis and dysplasia. The clinical presentation is not specific in MDS and initial symptoms are generally related to the underlying cytopenias. Thrombotic thrombocytopenic purpura (TTP) is a life threatening condition with thrombocytopenia and hemolytic anemia in which immediate initiation of treatment is critically important. Fragmented erythrocytes (schistocytes) are classically observed in TTP and are rarely a sign for MDS. Herein, we aim to report a 41 year-old woman having thrombotic microangiopathy in admittance and then eventually diagnosed with MDS.

Keywords: Myelodysplastic Syndrome; Thrombotic Microangiopathy; Transplantation

References

  1. Sasaki N., et al. “Thrombotic thrombocytopenic purpura associated with myelodysplastic syndrome. International Journal of Hematology4 (2008): 457-459.
  2. Leone G., et al. “Acute onset of juvenile myelodysplastic syndrome mimicking thrombotic thrombocytopenic purpura and rapidly evolving in overt myeloid leukemia”. American Journal of Hematology1 (1992): 64-65.
  3. Kjelland JD., et al. “Acquired Elliptocytosis as a Manifestation of Myelodysplastic Syndrome with Ring Sideroblasts and Multilineage Dysplasia”. Case Reports on Hematology 2017 (2017): 3625946.
  4. Okabe M., et al. “A case of subacute-onset myelodysplastic syndrome with infection mimicking thrombotic thrombocytopenic purpura: a case report with literature review”. Renal Replacement Therapy 13 (2019).
  5. Moscoso Martínez SF., et al. “Myelodysplastic Syndrome Clinically Presenting with the "Classic TTP Pentad". Case Reports on Hematology 2017 (2017): 4619406.
  6. Doudenko-Pirozzolo I and Booth R. “Pathologic quiz case: a 20-year-old man with a history of hemoptysis and purpura”. Archives of Pathology and Laboratory Medicine 6 (2001): 835-837.
  7. Zahid MF., et al. “Genomic imbalances in peripheral blood confirm the diagnosis of myelodysplastic syndrome in a patient presenting with non-immune hemolytic anemia”. Leukemia Research Reports 5 (2016): 23-26.

Citation

Citation: Deniz Granit., et al. “Myelodysplastic Syndrome Mimicking Thrombotic Thrombocytopenic Purpura Treated with Allogeneic Bone Marrow Transplantation". Acta Scientific Gastrointestinal Disorders 6.4 (2023): 04-07.

Copyright

Copyright: © 2023 Deniz Granit., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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