Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Research Article Volume 6 Issue 3

Thrombocytopenia Association with H pylori Infection

Jawad Khan First, Saira Nasr Malik, Komal Iqbal, Ansa Rehman, Safia Rehman And Neelum Ahmad

Department of Hematology/Gastroenterology, Pakistan

*Corresponding Author: Saira Nasr Malik, Department of Hematology/ Gastroenterology, Pakistan.

Received: September 19, 2022; Published: February 22, 2022


Objective: To observe the presence of thrombocytopenia associated with confirmed chronic H pylori infection.

Study Design: Descriptive crossectional study.

Place and Duration of Study: Khyber Teaching Hospital and Police and Services Hospital Peshawar.

Methodology: Those patients who were diagnosed with confirmed H pylori infection where included in this study. Total number of patients were 230. Both out patients and admitted patients were included. The age range was between 20 to 70 years. strict exclusion criteria was followed as thrombocytopenia’s can be caused by multiple other diseases like HCV , HBV , cirrhosis due to other causes like autoimmune hepatitis, primary biliary cholangitis, NASH, primary sclerosing cholangitis, certain drugs , other autoimmune diseases affecting multiple organs like SLE. Also those patients were included who didn’t received any H pylori eradication therapy in past. H pylori was diagnosed by stool antigen which is the most sensitive test for H pylori diagnoses after confirming that patient was not on PPI and didn’t take any antibiotics in last 2 weeks. Platelets counts were measured by automated hematological analyzer followed by peripheral smear for confirmation. Data was analyzed by spss 17 and presented with frequencies and percentages, chi-square was applied and p value < 0.05 was considered as significant.

Results: Out of total 230 patients, 31 patients were found to have thrombocytopenia after following exclusion criteria. 19 out of 31 were above 50 years. Range of platelet counts were between 60000 to 100000, P value was 0.001. Number of male and female patients were same so gender difference was insignificant in this study.

Conclusion: Patients presenting with chronic H pylori infection did show thrombocytopenia especially in older patients above 50.

Keywords: Helicobacter pylori; Platelets; Proton Pump Inhibiters; Thrombocytopenia


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Citation: Saira Nasr Malik., et al. “Thrombocytopenia Association withH pylori Infection". Acta Scientific Gastrointestinal Disorders 6.3 (2022): 02-05.


Copyright: © 2022 Saira Nasr Malik., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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