Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Research Article Volume 6 Issue 3

Features of Calcium Homeostasis Among Patients with Malabsorption Syndrome on the Background of Chronic Kidney Disease

Zub LO, Shkarutyak AY and Buzdugan IO*

Department of Inter Medicine, Bukovinian State Medical University, Ukraine

*Corresponding Author: Buzdugan IO, Department of Inter medicine, Bukovinian State Medical University, Ukraine.

Received: April 25, 2022; Published: February 15, 2022

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Abstract

Background:Today, data on the role of factors of non-microbial etiology that form the combined pathology of the kidneys and gastrointestinal tract, remain scarce. Calcium homeostasis, which according to the medical literature plays an important role in the progression of renal pathology, especially when it is impaired among patients with malabsorption syndrome due to chronic kidney disease (CKD).

The Aim: The research was to study the processes of calcium homeostasis among patients with malabsorption syndrome on the background of chronic kidney disease.

Materials and Methods: 99 patients with malabsorption syndrome (MAS) on the background of CKD were examined. Patients were divided into groups: Group I (25 people) - Stages 1 and 2 of CKD without MAS; Group II (26) - Stages 1 and 2 of CKD with MAS; Group ІІІ (23)- Stage 3 of CKD without MAS; Group ІV (25) - Stage 3 of CKD with MAS.

According to the morphological study of in vivo biopsies of the small intestinal mucosa, mild and moderate morphological changes were observed among all patients. The level of calcium and phosphorus in the blood, as well as calcium in the urine were detected. At the same time, the level of calcium-regulating hormones in the blood - parathyroid hormone and calcitonin - was studied.

The Results of the Research: Pathological changes in calcium metabolism were observed among patients with malabsorption syndrome. The severity of these disorders was more evident among patients with Stage 3of CKD. Calcium levels in daily urine were reduced in groups III and IV. No changes were detected in phosphorus metabolism. Changes in parathyroid hormone and osteocalcin are caused primarily by combined renal pathology with impaired renal calcium absorption.

Conclusion: Patients with malabsorption syndrome on the background of CKD revealed deeper violations of calcium homeostasis, which can lead to rapid progression of this combined pathology involvinga bone tissue in the pathological process.

Keywords: Malabsorption Syndrome; Chronic Kidney Disease; Calcium

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Citation

Citation: Buzdugan IO., et al. “Features of Calcium Homeostasis Among Patients with Malabsorption Syndrome on the Background of Chronic Kidney Disease". Acta Scientific Gastrointestinal Disorders 6.3 (2022): 25-28.

Copyright

Copyright: © 2022 Buzdugan IO., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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