Ahmet Özer Şehirli*

Near East University, Faculty of Dentistry, Department of Pharmacology, Turkey

*Corresponding Author: Ahmet Özer Şehirli, Near East University, Faculty of Dentistry, Department of Pharmacology, Turkey.

Received: January 17, 2022; Published: February 01, 2022

The potential for side effects is the most important factor limiting the treatment in treatments performed during cancer, which is one of the most important problems of recent times [1]. Some of the agents used in this treatment are also used in the treatment of autoimmune diseases due to their immunosuppressive properties. One of the side effects of these agents is the damage they cause in the gastrointestinal tract, which is manifested by symptoms of nausea-vomiting, diarrhea/constipation [2]. It is a condition that occurs as a result of the agents used during chemotherapy affect not only the tumor cell but also healthy cells. Free oxygen radicals, as well as neurotransmitters and hormones such as dopamine, serotonin, histamine, norepinephrine, vasoactive intestinal peptide, gastrin, vasopressin, thyrotropine-releasing hormone, leucine-enkephalin and substance-P, in the damage in the gastrointestinal tract, increase in inflammatory cytokine levels, decrease in endogenous anti-inflammatory and antioxidant enzyme activations play an important role [2-4] Therefore, although the studies carried out to correct this situation are increasing day by day, it still continues to be a problem as a clinic. For this purpose, studies with anti-inflammatory and immunomodulatory drugs with antioxidant properties have accelerated, and the development of nanoparticles that only selectively affect tumor cells has been accelerated [5,6].

References

1. Çakır T., et al. “Caffeic acid phenethyl ester (CAPE) prevents methotrexate-induced hepatorenal oxidative injury in rats”. Journal of Pharmacy and Pharmacology 12 (2011): 1566-1571.
2. Topcuoglu P. “Gastrointestinal Sistem Toksisitesi”. Türk Hematoloji Derneği, Hematolojide Destek Tedavileri ve İnfeksiyonlar Kursu (2007): 35-45.
3. Çakır T., et al. “Does alfa lipoic acid prevent liver from methotrexate induced oxidative injury in rats?” Acta Cirúrgica Brasileira 4 (2015): 247-252.
4. Arpag H., et al. “Protective Effects of Alpha-Lipoic Acid on Methotrexate-Induced Oxidative Lung Injury in Rats”. Journal of Investigative Surgery 2 (2018): 107-113.
5. Akyuz C., et al. “Effects of melatonin on colonic anastomosis healing following chemotherapy in rats”. Singapore Medical Journal 10 (2018): 545-549.
6. Lotfi M., et al. “The protective effects of quercetin nano-emulsion on intestinal mucositis induced by 5-fluorouracil in mice”. Biochemical and Biophysical Research Communications 585 (2021): 75-81.

Citation

Citation: Ahmet Özer Şehirli. “Effects of Drugs Used in Cancer Treatment on The Gastrointestinal Tract". Acta Scientific Gastrointestinal Disorders 5.3 (2022): 01.

Copyright

Copyright: © 2022 Ahmet Özer Şehirli. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.