Acta Scientific Gastrointestinal Disorders (ISSN: 2582-1091)

Mini ReviewVolume 4 Issue 8

Molecular Crosstalk amongst Anti-Orexigenic Ghrelin and Adenosine Monophosphate-Activated

Akanksha Singh*

Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, India

*Corresponding Author: Akanksha Singh, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, India.

Received: July 12, 2021; Published: July 26, 2021

Citation: Akanksha Singh. “Molecular Crosstalk amongst Anti-Orexigenic Ghrelin and Adenosine Monophosphate-Activated Protein Kinase (AMPK)". Acta Scientific Gastrointestinal Disorders 4.8 (2021): 66-67.


Ghrelin has proved to be a crucial mediator in stimulation of obesity. It elevates appetite by eliminating the action of GHS-R1a of neurological NPY/AgRP thus enhancing orexigenic activity. Such negative effects had been neutralized by the production of auto-ghrelin antibodies which are self-catalytic neutralizing the obese conditions by directly targeting AMPK active site which is known to stimulate appetite. Suppression of AMPK thus playing a central role might stimulate the activation of GHS-R1a thus leading to controlled release of ghrelin hormone. In this study, when mice were fed with high calorie diet exposed to the anti- ghrelin antibodies prepared by ELISA technique, after few hours, anti- ghrelin showed maximum activity thus decreasing ghrelin levels originally present. The study mainly focusses on the determining the interaction occurring between obese mediated ghrelin molecule and AMPK.

Keywords: Ghrelin; GHS-R1a; NPY/AgRP; Orexigenic; AMPK; ELISA; Obesity


  1. ‘2722_WOF_-_COVID-19_and_Obesity-The_2021_Atlas_WEB.pdf’ (no date) (2021).
  2. Trayhurn P. “The biology of obesity”. The Proceedings of the Nutrition Society1 (2005): 31-38.
  3. Alvarez-Crespo M., et al. “The amygdala as a neurobiological target for ghrelin in rats: neuroanatomical, electrophysiological and behavioral evidence”. PloS one 10 (2012): e46321.
  4. Delporte C. “Structure and physiological actions of ghrelin”. Scientifica (2013): 518909.
  5. Lim CT., et al. “AMPK as a mediator of hormonal signalling”. Journal of Molecular Endocrinology2 (2010): 87.
  6. Florant GL., et al. “To eat or not to eat: the effect of AICAR on food intake regulation in yellow-bellied marmots (Marmota flaviventris)”. Journal of Experimental Biology12 (2010): 2031-2037.
  7. Kim J., et al. “AMPK activators: mechanisms of action and physiological activities”. Experimental and Molecular Medicine4 (2016): e224-e224.
  8. Jeon SM. “Regulation and function of AMPK in physiology and diseases”. Experimental and Molecular Medicine7 (2016): e245-e245.
  9. Huynh MKQ., et al. “Hypothalamic AMPK as a regulator of energy homeostasis”. Neural Plasticity (2016).

Copyright: © Akanksha Singh. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is May 30, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US