Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Review Article Volume 4 Issue 2

The Role of Oxidative Stress and Antioxidant Effects in Female Endometriosis: A Systematic Review

Ashish Ashish1, Kusum Kusum2, Sangeeta Rai3, Kulsoom Zahra4, Surendra Pratap Mishra4 and Royana Singh1*

1Department of Anatomy, Institute of Medical Science, Banaras Hindu University, Varanasi, India
2Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, India
3Department of Obstetrics and Gynaecology, Institute of Medical Science, Banaras Hindu University, Varanasi, India
4Department of Biochemistry, Institute of Medical Science, Banaras Hindu University, Varanasi, India

*Corresponding Author: Royana Singh, Department of Anatomy, Institute of Medical Science, Banaras Hindu University, Varanasi, India..

Received: January 05, 2021; Published: January 30, 2021

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Abstract

  Endometriosis is an estrogen-dependent chronic inflammatory disease associated with substantial morbidity, including dyspareunia, dysmenorrhea, pelvic pain, multiple surgery, and infertility. This disease has a high impact on both woman’s physical and mental well-being. The etiology of endometriosis is complex and multifactorial, influenced by genetic, epigenetic, elevated reactive oxygen species (ROS), and oxidative stress. These factors have been postulated to play an essential role in endometriosis pathogenesis. The mitochondria are central in cellular inflammation and also a source of reactive oxygen species (ROS) in endometriosis. They are targets of ROS, and many different cellular signals like NFκB are activated due to Retrogate mensuration and ROS. These signaling pathways are responsible for the activation of apoptotic pathways in the cells of Immunity like JNK, Caspases, and IKK. This review defines molecular events linking, oxidative stress, and mitochondria, which lead to Mitochondrial Dysfunction and Apoptosis instability, alterations associated with endometriosis, its mechanisms, and pathways related to oxidative stress in ectopic peritoneal lesions.

Keywords: Endometriosis; ROS; Mitochondrial Dysfunction; Infertility; Oxidative Stress

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References

  1. Bulletti C., et al. “Endometriosis and infertility”. Journal of Assisted Reproduction and Genetics 27 (2010): 441-447.
  2. About Endometriosis - Endometriosis Society of India.
  3. Y Weintraub A. “Think Endometriosis: Delay in Diagnosis or Delay in Referral to Adequate Treatment?” Journal of Fertilization: In vitro - IVF-Worldwide, Reproductive Medicine, Genetics and Stem Cell Biology3 (2014).
  4. Zondervan KT., et al. “Endometriosis”. Nature Reviews Disease Primers 1 (2018): 9.
  5. Laganà AS., et al. “The pathogenesis of endometriosis: Molecular and cell biology insights”. International Journal of Molecular Sciences 22 (2019): 1-42.
  6. Moradi M., et al. “Impact of endometriosis on women’s lives: A qualitative study”. BMC Womens Health1 (2014): 123.
  7. Taylor HS., et al. “An evidence-based approach to assessing surgical versus clinical diagnosis of symptomatic endometriosis”. International Journal of Gynecology and Obstetrics 2 (2018): 131-142.
  8. Surrey ES., et al. “Treatment Patterns, Complications, and Health Care Utilization Among Endometriosis Patients Undergoing a Laparoscopy or a Hysterectomy: A Retrospective Claims Analysis”. Advances in Therapy11 (2017): 2436.
  9. Snyder BM., et al. “Postmenopausal Deep Infiltrating Endometriosis of the Colon: Rare Location and Novel Medical Therapy”. Case Reports in Gastrointestinal Medicine 2018 (2018): 1-5.
  10. Houston diana e., et al. “Incidence of pelvic endometriosis in rochester, minnesota, 1970-1979”. American Journal of Epidemiology6 (1987): 959-969.
  11. Endometriosis month: 25 million Indian women suffer from painful condition that’s difficult to treat.
  12. Bulun SE. “Endometriosis”. The New England Journal of Medicine 3 (2009): 268-279.
  13. Wang X., et al. “A case of 2019 Novel Coronavirus in a pregnant woman with preterm delivery”. Clinical Infectious Diseases (2020).
  14. Mehedintu C., et al. “Endometriosis still a challenge”. Journal of Medicine and Life 7 (2014): 349-357.
  15. Negi N., et al. “Clinical outcome analysis and correlation of reproductive outcome with endometriosis fertility index in laparoscopically managed endometriosis patients: A retrospective cohort study”. Journal of Human Reproductive Sciences 2 (2019): 98.
  16. Sampson JA. “Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity”. American Journal of Obstetrics and Gynecology 4 (1927): 422-469.
  17. Gupta S., et al. “Theories on Endometriosis”. In: Springer Briefs in Reproductive Biology (2015): 17-21.
  18. Burney RO and Giudice LC. “Pathogenesis and pathophysiology of endometriosis”. Fertility and Sterility 98 (2012): 511-519.
  19. Kurutas EB. “The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: Current state”. Nutrition Journal 15 (2016).
  20. Zorov DB., et al. “Mitochondrial ROS-induced ROS release: An update and review”. Biochimica et Biophysica Acta - Bioenergetics 1757 (2006): 509-517.
  21. Agarwal A., et al. “Role of oxidative stress in female reproduction”. Reproductive Biology and Endocrinology 3 (2005) 28.
  22. Máté G., et al. “Endometriosis Is a Cause of Infertility. Does Reactive Oxygen Damage to Gametes and Embryos Play a Key Role in the Pathogenesis of Infertility Caused by Endometriosis?” Frontiers in Endocrinology (Lausanne) (2018): 9.
  23. Bresgen N and Eckl PM. “Oxidative stress and the homeodynamics of iron metabolism”. Biomolecules (2015): 808-847.
  24. Donnez J., et al. “Oxidative stress in the pelvic cavity and its role in the pathogenesis of endometriosis”. Fertility and Sterility5 (2016): 1011-1017.
  25. Redza-Dutordoir M., et al. “Activation of apoptosis signalling pathways by reactive oxygen species”. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 12 (2016): 2977-2992.
  26. Thorpe GW., et al. “Superoxide radicals have a protective role during H2O 2 stress”. Molecular Biology of the Cell 18 (2013): 2876-2884.
  27. Defrère S., et al. “Potential involvement of iron in the pathogenesis of peritoneal endometriosis”. Molecular Human Reproduction 7 (2008): 377-385.
  28. Heymann D. “Autophagy: A protective mechanism in response to stress and inflammation”. Current Opinion in Investigational Drugs 5 (2006): 443-450.
  29. Duque GA and Descoteaux A. “Macrophage cytokines: Involvement in immunity and infectious diseases”. Frontiers in Immunology 5 (2014).
  30. Santulli P., et al. “Protein oxidative stress markers in peritoneal fluids of women with deep infiltrating endometriosis are increased”. Human Reproduction1 (2015): 49-60.
  31. Scutiero G., et al. “Oxidative Stress and Endometriosis: A Systematic Review of the Literature”. Oxidative Medicine and Cellular Longevity 2017 (2017).
  32. Wang Y., et al. “Importance of reactive oxygen species in the peritoneal fluid of women with endometriosis or idiopathic infertility”. Fertility and Sterility5 (1997): 826-30.
  33. Polak G., et al. “Disrupted iron metabolism in peritoneal fluid may induce oxidative stress in the peritoneal cavity of women with endometriosis”. Annals of Agricultural and Environmental Medicine 4 (2018): 587-592.
  34. Nasiri N., et al. “Oxidative stress statues in serum and follicular fluid of women with endometriosis”. Cell Journal4 (2016): 582-587.
  35. Vallée A and Lecarpentier Y. “Curcumin and endometriosis”. International Journal of Molecular Sciences. MDPI AG 21 (2020).
  36. Agarwal A., et al. “The effects of oxidative stress on female reproduction: A review”. Reproductive Biology and Endocrinology 10 (2012): 49.
  37. Murphy AA., et al. “Lysophosphatidyl choline, a chemotactic factor for monocytes/T- lymphocytes is elevated in endometriosis”. The Journal of Clinical Endocrinology and Metabolism6 (1998): 2110-2113.
  38. Vitale SG., et al. “The Role of Oxidative Stress and Membrane Transport Systems during Endometriosis: A Fresh Look at a Busy Corner”. Oxidative Medicine and Cellular Longevity (2018).
  39. Samimi M., et al. “The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis: Basic science and new insights based on gene expression”. Journal of Cellular Physiology 234 (2019): 19384-19392.
  40. González-Ramos R., et al. “Involvement of the nuclear factor-κB pathway in the pathogenesis of endometriosis”. Fertility and Sterility6 (2010): 1985-1994.
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Citation

Citation: Royana Singh., et al. “The Role of Oxidative Stress and Antioxidant Effects in Female Endometriosis: A Systematic Review”. Acta Scientific Gastrointestinal Disorders 4.2 (2021): 23-32.




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