Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Case Report Volume 3 Issue 11

Recent Portal Vein Thrombosis in Liver Cirrhosis: A Case of Success in Reversion of Portal Hypertension

Thales Girardi May1, Felipe Fiorin Carmona1, Lígia Rodrigues Simonetti1, Jéssica Araújo Amparado1, Luis Fernando Joaquim2 and Rafael Lima Kahwage2*

1Department of General Medicine, Hospital Beneficente Santa Casa de Misericórdia de Ribeirão Preto, São Paulo, Brazil
2Department of General Internal Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

*Corresponding Author: Rafael Lima Kahwage, Department of General Medicine, Hospital Beneficente Santa Casa de Misericórdia de Ribeirão Preto, Campos Elísios, Ribeirão Preto, SP, Brazil.

Received: September 04, 2020; Published: October 15, 2020

×

Abstract

  Portal vein thrombosis is an unusual complication in patients with liver cirrhosis. In the current research of its genesis, an underlying prothrombotic state and a combination of local endothelial factors, family and/or acquired inheritance and other thrombophilic factors are demonstrated. This condition is described as a major cause of portal hypertension, whether the patient has liver dysfunction or not. Clinical and laboratorial diagnosis are complemented with imaging exams and are useful in the early diagnosis, since the treatment directly affects the morbidity and mortality of the disease. We aimed to describe a case of a recent portal vein thrombosis concomitantly with hepatic cirrhosis and thrombophilia. Partial recanalization of the thrombus was achieved with anticoagulant treatment and consequent reversal of signs and symptoms of portal hypertension.

Keywords: Portal Vein Thrombosis; Cirrhosis; Recanalization; Thrombophilia; Anticoagulation

×

References

  1. Webster GJ., et al. “Review article: portal vein thrombosis - new insights into aetiology and management”. Alimentary Pharmacology and Therapeutics 21 (2005): 1-9.
  2. Wang JT., et al. “Portal vein thrombosis”. Hepatobiliary and Pancreatic Diseases International 4 (2005): 515-518.
  3. Condat B and Valla D. “Nonmalignant portal vein thrombosis in adults”. Nature Clinical Practice Gastroenterology and Hepatology 3 (2006): 505-515.
  4. Ogren M., et al. “Trousseau’s syndrome - what is the evidence? A population-based autopsy study”. Thrombosis and Haemostasis 95 (2006): 541-545.
  5. Ponziani FR., et al. “Portal vein thrombosis: insight into physiopathology, diagnosis, and treatment”. World Journal of Gastroenterology 2 (2010):14355.
  6. Sarin SK., et al. “Toward acomprehensive new classification of portal vein thrombosis in patients with cirrhosis”. Gastroenterology 151 (2016): 574-577.
  7. Kocher G and Himmelmann A. “Portal vein thrombosis (PVT): a study of 20 non-cirrhotic cases”. Swiss Medical Weekly 135 (2005): 372-376.
  8. Simão A., et al. “Trombose da veia porta: importância do diagnóstico e tratamento precoces”. Liver Today: Boletim Informativo APEF 7 (2009): 4-5.
  9. Plessier A., et al. “A prospective multicentric follow-up study on 105 patients with acute portal vein thrombosis (PVT): Results from the european network for vascular disorders of the liver (en-vie)”. Hepatology 46 (2007): 310.
  10. Hoekstra J and Janssen HL. “Vascular liver disorders (II): portal vein thrombosis”. The Netherlands Journal of Medicine 67 (2009): 46-53.
  11. Boyer TD. “Management of portal vein thrombosis”. Clinical Gastroenterology and Hepatology 10 (2008): 699-700.
  12. Garcia-Pagán JC., et al. “Extrahepatic portal vein thrombosis”. Seminars in Liver Disease 28 (2008): 282-292.
  13. Amitrano L., et al. “Risk factors and clinical presentation of portal vein thrombosis in patients with liver cirrhosis”. Journal of Hepatology 40 (2004): 736-741.
  14. Rosendaal FR. “Venous thrombosis: a multicausal disease”. Lancet 353 (1999): 1167-1173.
  15. Ciccarelli O., et al. “Transjugular intrahepatic portosystemic shunt approach and local thrombolysis for treatment of early posttransplant portal vein thrombosis”. Transplantation 72 (2001): 159-161.
  16. Tripodi A., et al. “Hypercoagulability in cirrhosis: causes and consequences”. Journal of Thrombosis and Haemostasis 9 (2011): 1713-1723.
  17. Egawa H., et al. “Single center experience of 39 patients with preoperative portal vein thrombosis among 404 adult living donor liver transplantations”. Liver Transplantation 12 (2006): 1512-1518.
  18. Englesbe MJ., et al. “Portal vein thrombosis and survival in patients with cirrhosis”. Liver Transplantation 1 (2010): 83-90.
  19. Intagliata NM., et al. “Diagnosis, Development, and Treatment of Portal Vein Thrombosis in Patients With and Without Cirrhosis”. Gastroenterology6 (2019): 1582-1599.
  20. Villa E., et al. “Enoxaparin prevents portal vein thrombosis and liver decompensation in patients with advanced cirrhosis”. Gastroenterology 143 (2012): 1253-1260.
  21. La Mura V., et al. “Harmful and beneficial effects of anticoagulants in patients with cirrhosis and portal vein thrombosis”. Clinical Gastroenterology and Hepatology 16 (2018): 1146-1152.

 

×

Citation

Citation: Rafael Lima Kahwage., et al. “Mucin Secreting Poorly Differentiated Rectal Adenocarcinoma with Inguinal Metastasis: Is it Regional or Distant Metastasis? A Case Report and Review of Literature". Acta Scientific Gastrointestinal Disorders 3.11 (2020): 13-19.




Metrics

Acceptance rate35%
Acceptance to publication20-30 days

Indexed In




News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is May 30, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US