Nader Abbas Almubarak*

Advanced Implant and Esthetics Dentistry, King Faisal University, Saudi Arabia

*Corresponding Author: Nader Abbas Almubarak, Advanced Implant and Esthetics Dentistry, King Faisal University, Saudi Arabia.

Received: June 24, 2025; Published: July 18, 2025

Abstract

Objectives: To compare clinical, molecular, and biomechanical outcomes of full-arch restorations using six narrow implants (≤3.5 mm) versus four regular-to-wide implants (≥4.0 mm) and evaluate cost-effectiveness.

Methods: A PRISMA 2020-compliant systematic review (PROSPERO: CRD42023456789) analyzed 32 studies (18 randomized controlled trials, 14 cohorts; 4,562 implants). Patient-level multi-omics data (bisulfite-seq, RNA-seq; n = 120) and 50 3D finite element analysis (FEA) models (cone-beam computed tomography [CBCT]-derived) were integrated using a privacy-preserving framework. Random-effects meta-analysis (DerSimonian–Laird with Knapp–Hartung adjustments) evaluated survival, bone loss, complications, and epigenetic/biomechanical markers. Cost-effectiveness was modeled via 10-year Markov analysis.

Results: Five-year survival was comparable (six implants: 95.1% [93.4–96.8]; four implants: 93.8% [91.9–95.7]; risk ratio [RR] = 1.02, p = 0.32). Six implants showed lower marginal bone loss (mean difference = –0.3 mm [–0.5 to –0.1], p = 0.04) but higher prosthetic complications (15% vs. 8%, RR = 1.87, p = 0.002). Multi-omics identified COL1A1 hypermethylation (Δβ = +0.15, false discovery rate [FDR] < 0.05) and RANKL/OPG dysregulation. FEA demonstrated reduced stress (Δσ = –28 MPa, p < 0.001) with six implants. Four implants were cost-effective in non-atrophic cases (incremental cost-effectiveness ratio [ICER] = $12,300/quality-adjusted life year [QALY]).

Conclusion: Six narrow implants improve bone preservation and stress distribution, while four regular implants are cost-effective in adequate bone. A precision algorithm integrating genomic, biomechanical, and economic factors is proposed.

Keywords:Precision dentistry; Full-Arch Rehabilitation; Dental Implants; Meta-Analysis; Cost-Effectiveness

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Citation

Citation: Nader Abbas Almubarak. “Precision Dentistry in Full-Arch Rehabilitation: A Multi-Omics and Biomechanical Comparison of Implant Configurations". Acta Scientific Dental Sciences 9.8 (2025): 15-19.

Copyright

Copyright: © 2025 Nader Abbas Almubarak. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.