Acta Scientific Dental Sciences (ASDS)(ISSN: 2581-4893)

Review Article Volume 7 Issue 12

Commiphora Myrrh in Management of Periodontal Diseases: Review Article

Alaa Moustafa Attia1* and Mashael Alqhtani2

1Department of Basic and Clinical Oral Sciences, Division of Periodontology, Faculty of Dentistry, Umm Al-Qura University (Makkah), Saudi Arabia, and Faculty of Dentistry, AL-Azhar University (Assiut), Egypt
2Department of Basic and Clinical Oral Sciences, Division of Maxillofacial Pathology, Faculty of Dentistry, Umm Al-Qura University (Makkah), Saudi Arabia

*Corresponding Author: Alaa Moustafa Attia, Department of Basic and Clinical Oral Sciences, Division of Periodontology, Faculty of Dentistry, Umm Al-Qura University (Makkah), Saudi Arabia, and Faculty of Dentistry, AL-Azhar University (Assiut), Egypt.

Received: October 25, 2023; Published: November 27, 2023


Background and objectives: The herbal extracts in management of oral and other body diseases were increased in last decades due to potential benefits as antibacterial, anti-inflammatory and antioxidant properties. Commiphora myrrh (C. myrrh) has been used for treating different diseases including chronic inflammatory conditions as periodontal diseases. This review aims to provide updated information on the clinical effects of C. myrrh products in treatment of periodontal diseases. The collected data of these review article obtained from several electronic data bases (PubMed, Scopus, Google Scholar, and others), the review based on the antibacterial, anti-inflammatory, and clinical effectiveness of C. myrrh in treating of periodontal diseases then discussion for these knowledges. Conclusions: The current review suggested that C. myrrh extracts is an effective to improve oral hygiene. It demonstrated clinical effectiveness in reduction of dental plaque and gingival inflammation and used as an adjunct to mechanical plaque control and professional therapies of periodontitis patients. Furthermore, well designed studies are required to establish the efficacy of C. myrrh in controlling of subgingival biofilm and reducing the proinflammatory cytokines.

Keywords:Commiphora myrrh; Gingivitis; Periodontitis; Periodontal Therapy


  1. Berezow AB and Darveau RP. “Microbial shift and periodontitis”. Periodontology 20001 (2011): 36-47.
  2. Abullais Saquib S., et al. “Synergistic antibacterial activity of herbal extracts with antibiotics on bacteria responsible for periodontitis”. The Journal of Infection in Developing Countries 11 (2021): 1685-1693.
  3. Teughels W., et al. “Adjunctive effect of systemic antimicrobials in periodontitis therapy. A systematic review and meta-analysis”. Journal of Clinical Periodontology 47 (2020): 257-281.
  4. Kumar P., et al. “Herbal remedies for the treatment of periodontal disease--a patent review”. Recent Patents on Drug Delivery and Formulation 3 (2009): 221-228.
  5. Figueiredo LC., et al. “Propolis, Aloe Vera, Green Tea, Cranberry, Calendula, Myrrha and Salvia Properties against Periodontal Microorganisms”. Microorganisms10 (2022): 2172-2192.
  6. Shameem I. “Phytochemical and therapeutic potentials of Murr makki (Commiphora myrrha): A review”. Indian Journal of Applied Research9 (2018) :102-104.
  7. Abukhader R and Al Tawaha AR. “Amazing benefits of myrrh”. International Journal of Pharmaceutical Research2 (2021): 303-308.
  8. Alraddadi B and Shin H. “Biochemical properties and cosmetic uses of commiphora myrrha and boswellia serrata”. Cosmetics 9 (2022):119-134.
  9. Jassoma E., et al. “The antiplaque/anticariogenic efficacy of Salvadora persica (Miswak) mouthrinse in comparison to that of chlorhexidine: a systematic review and meta-analysis”. BMC Oral Health1 (2019): 64-78.
  10. Bassiouny G and Al Barrak H. “The Anti-plaque Effect of Miswak and Myrrh Mouthwashes versus Chlorhexidine in the Treatment of Chronic Gingivitis; A Comparative Clinical Trial”. Medical Science33 (2014): 32-37.
  11. Eid RAA. “Efficacy of Commiphora myrrh mouthwash on early wound healing after tooth extraction: A randomized controlled trial”. Saudi Dent Journal1 (2021): 44-54.
  12. Al-Marby A., et al. “Nematicidal and antimicrobial activities of methanol extracts of 17 plants of importance in ethnopharmacology, obtained from the Arabian Peninsula”. Journal of Intercultural Ethnopharmacology 5 (2016): 114-121.
  13. Baek, et al. “Effect of antibacterial effects of myrrh, rhatany, chamomomilla against to oral microorganisms”. Journal of Oral Medicine and Pain 38.4 (2013): 2288-9272.
  14. Abullais Saquib S., et al. “Synergistic antibacterial activity of herbal extracts with antibiotics on bacteria responsible for periodontitis”. The Journal of Infection in Developing Countries 15 (2021): 1685-1693.
  15. Lenka B., et al. “Myrrh oil reduces gingival inflammation and inhibits gram negative dental plaque bacteria at early stages - A randomized control trial”. Indian Journal of Forensic Medicine and Toxicology2 (2021): 3795-3805.
  16. Al-Madi EM., et al. “Comparison of the Antibacterial Efficacy of Commiphora molmol and Sodium Hypochlorite as Root Canal Irrigants against Enterococcus faecalis and Fusobacterium nucleatum”. Evidence-Based Complementary and Alternative Medicine 4 (2019):1-4.
  17. ALHarthi S., et al. “Myrrh mixed with silver nanoparticles demonstrates superior antimicrobial activity against Porphyromonas gingivalis compared to myrrh and silver nanoparticles alone”. Saudi Dental Journal 33 (2021): 890-896.
  18. Weber L., et al. “Anti-Inflammatory and Barrier-Stabilising Effects of Myrrh, Coffee Charcoal and Chamomile Flower Extract in a Co-Culture Cell Model of the Intestinal Mucosa”. Biomolecules 10 (2020): 1033-1044.
  19. Shalaby MA and Hammouda AA. “Analgesic, anti-inflammatory and anti-hyperlipidemic activities of Commiphora molmol extract (Myrrh)”. Journal of Intercultural Ethnopharmacology2 (2014): 56-62.
  20. Haffor AS. “Effect of myrrh (Commiphora molmol) on leukocyte levels before and during healing from gastric ulcer or skin injury”. Journal of Immunotoxicology1 (2010): 68-75.
  21. Fatani AJ., et al. “Myrrhattenuates oxidative and inflammatory processes in acetic acid-induced ulcerative colitis”. Experimental and Therapeutic Medicine 2 (2016): 730-738.
  22. Shin JY., et al. “Commiphora myrrha inhibits itch-associated histamine and IL-31 production in stimulated mast cells”. Experimental and Therapeutic Medicine 3 (2019): 1914-1920.
  23. Tatakis DN and Kumar PS. “Etiology and pathogenesis of periodontal diseases”. Dental Clinics of North America3 (2005): 491-516.
  24. Tipton DA., et al. “In vitro cytotoxic and anti-inflammatory effects of myrrh oil on human gingival fibroblasts and epithelial cells”. Toxicology In Vitro 3 (2003): 301-310.
  25. Tipton DA., et al. “Effect of myrrh oil on IL-1beta stimulation of NF-kappaB activation and PGE (2) production in human gingival fibroblasts and epithelial cells”. Toxicology In Vitro.2 (2006): 248-255.
  26. Taheri JB., et al. “Herbs in dentistry”. International Dental Journal 6 (2011): 287-296.
  27. Zahid T and Alblowi J. “Anti-Inflammatory and Anti-Plaque Effects of Commiphora Myrrh Mouthwash: A Preliminary Pilot Clinical Study”. The Open Dentistry Journal 12 (2019): 1-5.
  28. Zahid Talal and Khan N. “Myrrh and Chlorhexidine Mouthwashes Comparison for Plaque, Gingivitis and Inflammation Reduction: A 3-Arm Randomized Controlled Trial”. Annals of Dental Specialty1 (2022): 39-47.
  29. Alotaibi R., et al. “The Effects of Commiphora Myrrh Mouthwash Verses Chlorhexidine on Dental Plaque and Gingivitis: A Comparative Study”. Journal of Research in Medical and Dental Science8 (2020): 65-70.
  30. Schaudinn C., et al. “Periodontitis: An archetypical biofilm disease”. The Journal of the American Dental Association 140 (2009): 978-986.
  31. Chatzopoulos GS., et al. “Clinical Effectiveness of Herbal Oral Care Products in Periodontitis Patients: A Systematic Review”. International Journal of Environmental Research and Public Health 19 (2022): 10061-10078.
  32. Al-Mobeeriek A. “Effects of myrrh on intra-oral mucosal wounds compared with tetracycline- and chlorhexidine-based mouthwashes”. Clinical, Cosmetic and Investigational Dentistry 3 (2011): 53-58.


Citation: Alaa Moustafa Attia and Mashael Alqhtani. “Commiphora Myrrh in Management of Periodontal Diseases: Review Article".Acta Scientific Dental Sciences 7.12 (2023): 42-46.


Copyright: © 2023 Alaa Moustafa Attia and Mashael Alqhtani. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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