Acta Scientific Dental Sciences (ASDS)(ISSN: 2581-4893)

Editorial Volume 6 Issue 11

Regeneration Therapy: Editorial Note

Michel Goldberg*

Professor, Department of Oral Biology, France Université, Paris Descartes

*Corresponding Author: Michel Goldberg, Professor, Department of Oral Biology, France Université, Paris Descartes.

Received: September 23, 2022; Published: October 01, 2022


Necrosis of the root periapex and pulp is the usual consequence of carious decay. Its involves endodontic treatment. Recently, root and pulp regeneration were promoted. Indeed, a number of STEM cells may penetrate the canal, sliding from the periapex toward the lumen of the canal. Bone marrow mesenchymal stem cells (BMMSCs) give rise to osteogenic, chondrogenic, and adipogenic SC. In addition, myogenic, neurogenic and tenogenic cells may derived from BMMSCs. Markers that are consistently reported are STRO-1, CD73, CD90, CD105, CD146, Oct4, Nanog, beta2 integrin, whereas CD14, CD34, CD45, and HLA-DR display negative expression. Investigations of dental pulp regeneration have been published [1], isolating a side population (SP) of cells from dental pulp based on the efflux of fluorescent dye Hoechst 33342. These SP cells, derived from porcine dental pulp, differentiate into odontoblasts in response to BMP-2. Dental pulp stem cells (DPSC) are obtained from deciduous or exfoliated tooth, or from permanent teeth (SHED), from the apical papilla (SCAP), from cementum-like cells, from the periodontal ligament (PDL), and SC of the dental follicular sac.


  1. Iohara K., et al. “Side population cells isolated from porcine dental pulp tissue with self-renewal and multipotency for dentinogenesis, chondrogenesis, adipogenesis, and neurogenesis”. Stem Cells 24 (2006): 2493-2503.
  2. Huang GTJ., et al. “Mesenchymal stem cells derived from dental tissues vs. those of other sources: their biology and role in regenerative medicine”. Journal of Dental Research 9 (2009): 792-806.
  3. Tatullo M., et al. “Dental pulp stem cells: function, isolation and applications in regenerative medicine”. Tissue Engineering and Regenerative Medicine 11 (2014: 1205-1216.


Citation: Michel Goldberg. “Regeneration Therapy: Editorial Note". Acta Scientific Dental Sciences 6.11 (2022): 01-02.


Copyright: © 2022 Michel Goldberg. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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